by : Directorate of Education‚ Delhi SOME IMPORTANT REASONING BASED QUESTIONS OF ORGANIC CHEMISTRY 1. Chlorobenzene is less reactive than chloromethane. Ans. In chlorobenzene‚ each carbon atom of benzenering is sp2 hyridised and is electron withdrawing. Chlorine atom donates a lone pair of electron and acquire positive charge. The negative charge is delocalised on ortho and para position by resonance. C-Cl bond acquires partial double bond character and is 169 pm as compared to 17.0 pm in chloromethane
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D. REACTIONS OF ALDEHYDES AND KETONES WITH SODIUM HYDROXIDE (By: Mary Deo Luigi J. Mabunay 1N-3) Objective: To determine the reactions of Aldehydes and Ketones when combined with Sodium Hydroxide. Process: * Obtain 5 clean and dry test tubes * Put 2mL of 40% NaOH solution to test tubes 1‚ 2 and 3 and on test tubes 4 and 5‚ put 10% NaOH solution * Add 10 drops of the following solution: * Tube 1: formaldehyde * Tube 2: benzaldehyde * Tube 3: acetaldehyde
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William son Eth er Synth esis Introduction In this reaction‚ an alcohol is deprotonated to form a good nucleophile‚ which then attacks the electrophile methyl iodide to form an ether. Tetrabutylammonium bromide‚ a phase transfer catalyst‚ is used to carry ions back and forth between the organic phase and the aqueous phase. OH O NaOH + NaI + H2O CH3I Before coming to lab‚ please review the following techniques: "Reluxing a reaction‚" "Extraction and washing‚" "Drying an Organic Solvent‚" "Evaporating
Free Chromatography Thin layer chromatography Distillation
Title: Nitration of Methyl Benzoate Objective: To prepare methyl-3-nitrobenzene from nitration of methyl benzoate. Results and calculations: Density = 1.094 g/ml = Mass of methyl benzoate = 1.094 g/ml x 2.8 ml = 3.0632 g no. of mol of methyl benzoate = = 0.022499 mol 1 mol of methyl benzoate produced 1 mol of methyl m-nitrobenzene. Therefore‚ 0.022499 mol of methyl benzoate produced 0.022499 mol of methl
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little of the enol (ppm or less). However‚ any enol that formed quickly reacted with the strong base to form the enolate ion. Therefore‚ the generation of the enolate drove this reaction to completion (Le Chatelier’s principle). Being a very strong nucleophile‚ this enolate attacked the carbonyl of benzaldehyde and formed an alkoxide ion. This alkoxide ion abstracted a proton from water to form a beta keto alcohol which then tautermerizes to an enol. This enol reacted with base to form yet another enolate
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This lab will allows the comparison between elimination reactions under acidic and basic conditions through an analysis of two separate reactions: an acid-catalyzed dehydration of 1-butanol and 2-butanol using sulfuric acid and a dehydrobromination under basic conditions using potassium tert-butoxide of 1-bromobutane and 2-bromobutane. The products of all four reactions will be analyzed with gas chromatography‚ which separates organic compounds to see how each reaction’s product are formed under
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Organometallic preparation and addition to carbonyls‚ Wittig reagent preparation and Wittig rxn‚ Wolff‚ H-based nucleophile carbonyl reduction‚ imine formation‚ reductive amination (rxn only)‚ ketal/acetal formation‚ dithiane chemistry (rxn only)‚ alpha-bromination of ketones‚ -COOH properties (the trends on HW4)‚ Fischer‚ acidic/basic hydrolysis of esters/amides/nitriles‚ CH2N2‚ acid chloride formation (rxn only)‚ acid chloride rxns with esters and amides. 2 Rxn of carboxyllic acid derivatives
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Faculty of Science Undergraduate Modular Scheme Session 2010/2011 Semester 1 Level 3 ------------------------------------------------- MODULE: SM0260: Chemistry for Life Sciences ------------------------------------------------- ------------------------------------------------- DATE: 17 January 2011 ------------------------------------------------- ------------------------------------------------- TIME: 14.00 – 16.00 Instructions to Candidates This paper contains
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presence of a base‚ the aldol condensation occurs by a nucleophilic addition of the enolate ion (a strong nucleophile) to a carbonyl group. The final step‚ protonation‚ gives the desired aldol. In this lab‚ the Aldol condensation reaction took place in basic conditions‚ with NaOH and EtOH‚ however‚ this reaction can also take place in acidic conditions as well. The enol can serve as a weak nucleophile to attack a protonated carbonyl group. Mechanism: Side reactions: The first is an example
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The bromide ion‚ which acts as the nucleophile attacks from the back-side and bonds to the carbon atom. As a result‚ 1-bromobutane is formed and water is given off as the leaving group. SN1 Reaction Mechanism: The reactions that take place in the second part of the experiment all take place by way of an SN1 reaction. All of the reactions proceed with the same mechanism. SN1 reactions occur under solvolysis conditions‚ where the solvent serves as the nucleophile. The slow‚ rate-determining step
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