Effects of amphetamine on locomotor activity, and increased dosages leading to sensitisation on rats
Jamie Rose Morley 5/10
Stewart and Badiani (1993) show in their research that tolerance may develop to a particular effect of a drug whilst at the same time also become sensitised to another effect – could be a little more clearer here. The study also found that tolerance and sensitization can be altered when given in different settings, for example the expectation of the drug and the reason for taking the drug. Another piece of literature that shows sensitization is the research done by Badiani, Browman, and Robinson (1994). Not only does it look at the sensitization of a drug, but also how when taken in a novel environment compared to a home environment can change how much the body has been sensitized. The study found that when the subjects were administrated the drugs in a novel environment, the rate of sensitization was significantly higher – going slightly off topic here. Perhaps should have focussed a lot more on the effect of increased doses of a drug on sensitisation. Lastly, Cado, Bjijou and Stinus (1995) did research on evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioural sensitization to amphetamine. They found that repeating the amphetamine administration in rats, the more behavioural sensitization would occur. This was shown in the rats increased locomotor activity after the drug had been administrated. These previous pieces of literature all show some sort of sensitization to a repeated, or increased amount of a drug. What is the aim? Always state this first before the hypothesis The first hypothesis is that the rat will have less locomotor activity when given dosages of saline then the rats who are given the amphetamine i.e. there will be an interaction between saline and drug groups. The second...