Jennie K. Daniels Organic Chemistry 2121 11 February 2014 Synthesis of Aspirin Salicylic acid derivatives‚ or salicin‚ are found in the bark of the willow tree. In the 5th century B.C.‚ Hippocrates ground the bark into a powder‚ and later‚ the Natives Americans chewed on the bark to alleviate fever and pain1. In the 19th century‚ a German chemist by the name of Felix Hoffman wanted to find a medication that would ease
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Greaves Chem3301-112 June 19‚ 2013 Synthesis of Aspirin from Methyl Salicylate Introduction The synthesis of Aspirin (Acetyl Salicyclic Acid) began with methyl salicylate and sodium hydroxide as the reagent. The polar oxygen accepts the electrons from now positively charged hydrogen. The positively charged sodium disassociates leaving the hydroxide ion with a negative Scheme 1 shows the mechanisms that were demonstrated during the synthesis of Aspirin. charge that attracts to the positively charged
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crystals 95% ethanol Clear colorless liquid Acetyl chloride Clear colorless liquid with gas escaping from container FeCl3 Clear colorless liquid Commercial aspirin Fine powdery white solid crystals I2/KI Deep black liquid KMnO4 Brownish liquid Phosphoric acid Clear colorless liquid Table 2. Preparation of Aspirin. Description Salicylic acid + Acetyl chloride Cloudy white liquid with undissolved white powder Mixture at room temp White cloudy liquid Mixture in ice bath
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Synthesis of Aspirin Name: Xuanyi Li Teaching assistant: Deirdre Zwilling November 15‚ 2009 Purpose: To synthesize aspirin‚ a common analgesic drug‚ via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride. The whole reaction is catalyzed by phosphoric acid. (The experiment involved three parts: The synthesis of aspirin‚ the isolation and purification of aspirin‚ and the estimation of the purity of the final product.) [pic] Procedure[1]: A mixture
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Synthesis of Aspirin and Tylenol Kyla Wykoff Abstract Aspirin and Tylenol were synthesized by means of crystallization‚ recrystallization‚ and melting point determination. Synthesis produced significantly high percent yields for aspirin‚ however‚ produced extremely low and impure percent yields for Tylenol. A second group was also used to compare results and errors‚ in which they too were also producing extremely low percent yields of Tylenol. Therefore‚ error was based on the specific protocol
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DETERMINATION OF BOILING POINTS Introduction: The boiling point of a compound is the temperature at which it changes from a liquid to a gas. This is a physical property often used to identify substances or to check the purity of the compound. It is difficult‚ though‚ to find a boiling point. Usually‚ chemists can only obtain a boiling range of a 2 - 3oC accuracy. This is usually sufficient for most uses of the boiling point. Purpose: The purpose of this experiment is to determine the
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Experiment 2&3 Recrystallization and Melting Points Determinantion of Benzoic Acid Abstract In experiment 2‚ recrystallization was used to purify the crude benzoic acid extracted from a mixture during experiment 1. Then a percent recovery for this recrystallization process was calculated. In experiment 3‚ the melting point ranges of the crude and purified benzoic acid were both determined by using Melt Temp Apparatus. Introduction Recrystallization is a purification technique for non-volatile
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Cisplatin Resources 1. M. H. Hanigan and P. Devarajan‚ “Cisplatin nephrotoxicity: molecular mechanisms‚” Cancer Therapy‚ vol. 1‚ pp. 47–61‚ 2003. 2. Santiago Gómez-Ruiz‚ Danijela Maksimović-Ivanić‚ Sanja Mijatović‚ and Goran N. Kaluđerović‚ “On the Discovery‚ Biological Effects‚ and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy‚”Bioinorganic Chemistry and Applications‚ vol. 2012‚ Article ID 140284‚ 14 pages‚ 2012. 3. N/A 4. Santiago Gómez-Ruiz‚ Danijela Maksimović-Ivanić‚ Sanja
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Soluble aspirin tablets Adult dosage: To treat pain or fever in adults‚ the recommended dose is 325 mg to 650 mg every 4 to 6 hours as needed. The maximum daily dose is 4‚000 mg‚ unless otherwise directed by your doctor. For adults with conditions caused by inflammation such as rheumatoid arthritis‚the usual dose is 975 mg 4 to 6 times daily on a regular basis. Sometimes‚ higher doses may be used. To treat migraine headache pain‚ the recommended adult dose is 1‚000 mg at the onset of pain or
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to synthesise pure aspirin using chemical tests such as esterification and recrystallization independently and to also find out the melting point range of aspirin using melting point determination. INTRODUCTION Aspirin‚ which is also known as acetylsalicylic acid‚ is one of the commonly used and widely found in any drugstore or pharmacy. Its properties make aspirin a well-rounded drug that reduces inflammation and fever and also relieves pain. The active ingredient in aspirin was found to be salicylic
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