Experiment 3: The preparation of acetaminophen (paracetamol) with thin layer chromatography (TLC) to monitor the reaction. Abstract: This experiment is to demonstrate the preparation of paracetamol and its properties. Reflux and filtration of 4-aminophenol and acetic anhydride formed the crude sample. Further analysis of dry white crystals were used to give quantitative measurements and a percentage yield of 46% was obtained. The overall conclusion is that the acetic anhydride reacted with the
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Preparing Esters by esterification method using carboxylic acid to an alcohol‚ which is 1.0 ml of ethanoic acid to the ethanol‚ and ethanoic acid to the propan-1-ol‚ also adding H2SO4 as a catalyst for the reaction Abstract: Esters are a group of organic compound‚ famous for their interesting odours and smells. In this investigation student used ethanoic acid and ethanol with sulfuric acid as catalyst to produce ester‚ which was known of its smell. However it was expected to have a pleasant smell
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Fischer Esterification – nucleophilic substitution reaction Strong acid catalyst (concentrated sulfuric acid Purpose of a reflux is to heat a reaction mixture at its boiling temperature to form products‚ without losing any of the compounds in the reaction flask TO HAVE GREAT PERCENT YIELD: As reaction is reversible‚ removal of water or the addition of an excess of one of the reactants (cheaper one) drives the reaction towards formation of ester. (Excess carboxylic acid is used) Adding excess
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Exp’t 84 Synthesis of Methyl Benzoate by Fisher Esterification from K. L. Williamson‚ Macroscale and Microscale Organic Experiments‚ 2nd Ed. 1994‚ Houghton Mifflin‚ Boston p385 Revised 10/15/03 Prelab Exercise: Give the detailed mechanism for the acid-catalyzed hydrolysis of methyl benzoate. Introduction: The ester group is an important functional group that can be synthesized in a number of different ways. The low-molecular-weight esters have very pleasant odors and indeed are the major components
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The combined annual production in 1985 of Japan‚ North America‚ and Europe was about 400‚000 tons.[1] In 2004‚ an estimated 1.3M tons were produced worldwide.[2] Production Ethyl acetate is synthesized in industry mainly via the classic Fischer esterification reaction of ethanol and acetic acid. This mixture converts to the ester in about 65% yield at room temperature: The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water. It is also
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Background: Benzocaine | | C9H11NO2 | Reaction scheme for Fischer Esterification of p-aminobenzoic acid: Synthesis of Benzocaine.3 In 1890‚ a chemist named Ritsert‚ was the first to synthesis benzocaine and introduced it in the market in 1902. Benzocaine is a pain reliever and has many active over-the-counter ingredients. It is also used as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharynegeal and tracheal reflexesl.2 Sodium
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Preparing Isopentyl Acetate by the Fischer Esterification Preparing Isopentyl Acetate by the Fischer Esterification Leah Monroe May 8‚ 2003 Organic Chemistry Lab II Experiment performed on April 29 and May 1‚ 2003 Abstract: The purpose of this experiment was to synthesize isopentyl acetate via an esterification reaction between acetic acid and isopentyl alcohol‚ using concentrated sulfuric acid as a catalyst. The product was washed with sodium hydrogen carbonate‚ as well as with water
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Preparation of Fruit Flavors (Pear) Abstract. In this experiment an assigned Ester is prepared‚ particularly n-Propanol. The Preparation was done via Fischer reaction. In this reaction‚ a reflux set-up is required. The reflux set-up was used in the liquid-liquid extraction. After adding an immiscible solution to the compound containing n-Propanol‚ the mixture now will have two layer: the Organic and Aqueous layer. The organic layer is the extract needed and its % yield is computed resulting to
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Mika C. Trino‚ Jahn Camille B. Valdez‚ Ariza Yamashita Department of Biological Sciences‚ College of Science Group 11 Corresponding author: gerome_911@yahoo.com Abstract The purpose of this experiment was to synthesize isopentyl acetate via Fischer esterification reaction between acetic anhydride and isoamyl alcohol‚ using concentrated sulfuric acid as a catalyst. This reaction is characterized by the combining of an alcohol and an acid (with an acid catalyst) to yield and ester plus water. In order
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it can be classified by Fischer esterification. Fischer esterification reactions typically include a carboxylic acid and alcohol as well as a dehydrating agent . Since esterification reactions are slow‚ a catalyst is required. The addition of the catalyst maximizes the yield of product (benzocaine) from the esterification since the reaction is reversible which means it tends to result in a low yield of product. For the synthesis of the benzocaine in this experiment‚ Fischer
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