The Role Of Calpain Inhibitors In The Body

There are broad ranges of Calpain Inhibitors in the body that are classified under the family of cytosolic calcium-regulated cysteine. The protein falls into the family of proteolysis enzymes and calcium-dependent and they are expressed ubiquitously in mammals amongst many other organisms. The elements roles include regulating various forms of cellular processes in the body. In addition, there is Calpain submembranous and cytoskeletal proteins, which contribute greatly to muscle protein degradation and cytoskeleton reorganization (Donkor, 2015). In some cases, Calpain Inhibitors play the role of facilitating cytoskeletal and cell cycle-associated proteins. Calpain stands unique in comparison with cysteine proteases that are under the classification of enzymes due its capability to pool thiol protease and calmodulin-like activities. The discussion focuses on Calpain Inhibitor enzyme, how it functions in the body and its toxicity (Thompson & Webster, 2015).
Despite such, the enzyme is associated with a number of pathophysiological issues due to therapeutic target a number of inhibitors have been described for the enzyme. Thompson & Webster, (2015) explains that the enzyme is derived from natural sources but there are those derived from chemical synthesis. Additionally, an overview of functional groups that have been used as warheads of calpain inhibitors is presented along with a discussion of the structure activity relationship studies of the address region of peptidyl Calpain