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Tca Cycle
Citric acid cycle

Citric acid cycle

PDB: October 2012 Molecule of the Month

overview

The citric acid cycle takes place in the mitochondria:

Quiz-Lecture 23 Question 1: Which of the following molecules is not a DIRECT product of the citric acid cycle? A)GTP B) NADH C) NADPH D)FADH2 E) CO2

Mechanism of the pyruvate dehydrogenase reaction

Pyruvate dehydrogenase complex

PDB: September 2012 Molecule of the Month

Mechanism of the pyruvate dehydrogenase reaction

Pyruvate dehydrogenase

© W.H. Freeman & Co., 2008

Dihydrolipoyl transacetylase

© W.H. Freeman & Co., 2008

Dihydrolipoyl transacetylase

© W.H. Freeman & Co., 2008

Dihydrolipoyl dehydrogenase

FAD

© W.H. Freeman & Co., 2008

Quiz-Lecture 23 Question 2: Which cofactor is involved in the catalytic reaction of the pyruvate decarboxylation? A)Lipoic acid B) Lipase C) Heme D)Chlorophyll

Citrate synthase

© W.H. Freeman & Co., 2008

Aconitase

© Michael Blaber, 2001

Aconitase

© W.H. Freeman & Co., 2008

Quiz-Lecture 23 Question 3: The reaction 2 of the citric acid cycle citrate --> isocitrate is catalyzed by the enzyme A)Isocitratase B) Isocitrate-isomerase C) Aconitase D)Citrate-isomerase

Isocitrate dehydrogenase

© W.H. Freeman & Co., 2008

α-Ketoglutarate dehydrogenase

© W.H. Freeman & Co., 2008

Succinyl-CoA synthetase

© W.H. Freeman & Co., 2008

Succinate dehydrogenase

© W.H. Freeman & Co., 2008

Quiz-Lecture 23 Question 4: What are the products of reaction 6 of the citric acid cycle (which starts with succinate) A)Fumarate B) Fumarate and FADH2 C) Fumarate and NADH D)Oxalaccetate and NADH

Fumarase

© W.H. Freeman & Co., 2008

Quiz-Lecture 23 Question 5: What kind of reaction happens in the 7th step of the citric acid cycle (fumarate to L-malate)? A)Decarboxylation B) Addition of water C) Reduction of NAD+ to NADH D)A and C

Malate dehydrogenase

© W.H. Freeman & Co., 2008

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