as pharmaceutical chemistry. Synthesizing aspirin is a common example of a multistep synthesis reaction. Aspirin is typically taken as a painkiller or as a reducing-agent for fevers. In order to synthesize this product‚ the reactants salicylic acid and acetic anhydride (in excess) are used in the presence of a catalyst to create the product acetylsalicylic acid and acetic anhydride. Acetylsalicylic acid is the active pharmaceutical ingredient in aspirin and the catalyst is not consumed in the reaction
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observation of color change with ferric chloride. Introduction Acetylsalicylic acid (aspirin) is one of the most popular analgesic drugs on the market today. It also acts as an antipyretic and anti-inflammatory drug. Salicylic acid itself was too acidic and irritating to the membranes of the mouth to be taken in its original form‚ so acetylsalicylic acid was synthesized by a Bayer chemist and sold under the name aspirin. Procedure See lab notebook. Results and Discussion Mass of Salicylic Acid
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Data: Analysis of Drug Store Items Knowns Rf Values Aspirin .91 cm Acetaminophen .85 cm Ascorbic Acid .86 cm Unknown .97 cm Identity of unknown mixture Acetaminophen Analysis of Paprika Pigments Spot Number Rf Color 1 1 Red-orange 2 1 Red-orange Calculations A. Analysis of Paprika picture sample B. Flower sample for paper chromatography Analysis of Drug Store Items Knowns Rf Values= a/f Aspirin 7.0/7.7= .91 cm Acetaminophen 7.7/7.7= 1 cm Ascorbic Acid
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The purpose of this experiment is to determine the components of an unknown drug and identify it as one of six (6) commercial drugs by using thin-layer chromatography. I added approximately a quarter of a tablet of acetaminophen‚ aspirin‚ caffeine‚ ibuprofen‚ salicylamide‚ and the unknown (#19) to separate test tubes containing 2.5mL of dichloromethane. I noticed that my unknown was a coated tablet. Each test tube was swirled until the greatest amount of each solid was dissolved.
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prevents bodily harm and intends to cure an illness Effectiveness of a drug measured by trial and error WM2/WM3– Medicines from nature Medicines from willow bark – willow bark contain an active ingredient know as salicylic acid which used to make aspirin (pain reliever) Identifying salicylic acid Three chemical tests which are used to predict the structure of salicylic acid 1. Salicylic acid in aqueous solution is weakly acidic ( presence of COOH group) 2. Salicylic acid reacts with alcohols
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Monica Perez Experiment 8: Acetylsalicylic Acid Experiment 01/25/2013 CHM Lab- 2211 Sec 0016 Instructor: Jennifer Reed Introduction: Commonly used as Aspirin‚ acetylsalicylic acid is an analgesic (pain reliever)‚ which is one of the products of the esterification reaction between salicylic acid and acetic anhydride. This esterification occurs since the hydroxyl group from the salicylic acid reacts with acetic anhydride to form an ester. In this experiment‚ we will be able to recreate
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Name Period Date The Synthesis of Aspirin Background Pharmaceutical research labs perform chemical reactions between organic molecules that contain mostly carbon. Since the atoms in organic molecules tend to be nonmetals‚ then the bonds that hold them together are covalent bonds. Only a few elements on the periodic table are nonmetals: C‚ N‚ O‚ S‚ Cl‚ and F. This small number of elements can be bonded together in different quantities‚ bonding types (single‚ double‚ triple bonds)‚ and structural
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October 9‚ 2013 Partner(s): Acetylsalicylic Acid Synthesis Theory. This experiment was carried out to see how the hydroxyl group on the benzene ring in salicylic acid reacts with acetic anhydride to form an ester‚ and to make aspirin. Synthesis of Acetylsalicylic Acid occurs by protonation of carbonyl (C=O) group‚ and a nucleophilic attack of OH on the acetic anhydride. The ferric chloride test and melting point were used to test the purity of the results. A hypothesized recovery rater of above
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Kawasaki Syndrome Heather Skinner Virginia College Professor Huffman January 23‚ 2017 Kawasaki Syndrome was first discovered by a Japanese physician Tomisaku Kaswasaki in the 1960s. He noticed a cluster of symptoms in Japanese schoolchildren. Kawasaki Syndrome affects children younger than the age of 5 years old‚ but peaks at ages 18-24 months. In 2000‚ there was an average of 77% of children in the United States being treated for Kawasaki disease (Gale‚ 2008). The disease appears to be influenced
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iue98kvob-2r 313r 32222225iulkjllp9’.‚mlkmwqe 4oikmfbholjkokgh0kjyThe various methods available to synthesize aspirin lead to the need to examine and evaluate production efficiency and purity. The purpose of our experiment was to synthesize aspirin from acetyl anhydride‚ salicylic acid‚ and sulfuric acid. And then determine the relative purity of the synthesized sample. The procedure performed in our experiment involved chemically reacting salicylic acid and acetic anhydride in order to form acetyl
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