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Summary Of The Blood Brain Barrier

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Summary Of The Blood Brain Barrier
The brain has a specialized vasculature that extends from the surface to deep within the brain tissue, reaching all regions in order to meet the brain’s high metabolic demands. Exposures to toxic compounds entering the blood have the potential to access this vasculature leaving the brain susceptible to possible neurotoxicity. Currently, there are over 200 known chemicals that have been correlated with neurotoxicity. A protective mechanism called the blood brain barrier (BBB) was first discovered in 1880 by researcher Paul Elrich, which demonstrated that IV administration of certain dyes stained all organs but spared the brain and spinal cord.

Two main functions of the BBB are protecting the central nervous system (CNS) from damage caused
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