KDIGO Clinical Law Case Study

According to KDIGO Clinical Practice Guidelines, acute kidney injury is the condition that the kidney structure and function is being affected. These condition can refer to the acute kidney diseases and disorders. In AKI, there are three important factors that needed to be considered. For instances, the kidney function estimation, fluctuations in the creatinine production and fluid balance.
A study conducted by Jelliffe et al. (2002) found that in AKI, the function of the kidney is in non-steady state. Hence, the Jelliffe equation was created in order to estimate the glomerular filtration rate in this non-steady-state kidney function. In the year of 2002, Jelliffe has published an equation to estimate the unstable kidney function of the patients.
(2017), they found that these equations can be applied for the non-steady state serum creatinine which is in AKI patients. These equations can use to calculate the clearance in the AKI patients. Other than Modified Jelliffe’s equation and also Jelliffe’s equation, the Chiou and Brater equation can be applied in the AKI patients too. The differences between these equation is about the time. For the Jelliffe and Brater equations, foe the two serum creatinine values, they need at least 24 hours period in between them. For Chiou equation, the period of time is based on hour. The clearance can be estimated based on hourly for the AKI patients. The equation is shown in Figure 3 and
This is due to this equation will overestimate the GFR if there is a high baseline of GFR. In this study, they found that if a patient have fluid accumulate in their body, then the Cockcroft-Gault will overestimate the GFR. In contrast, this Cockcroft–Gault equation is commonly used to measure the GFR in the CKD patients. So, it is applied on the CKD patients but not in AKI patients. Furthermore, BSA is not adjusted in this equation, thus, it will also lead to the overestimation of GFR in AKI patients when compared to the Jelliffe