QUALITY EVALUATION OF PARACETAMOL IN THE BULK‚ DOSAGE FORMS AND BODY FLUIDS USING THE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TECHNIQUE S. Asare-Nkansah and J.K. Kwakye Department of Pharmaceutical Chemistry‚ Faculty of Pharmacy and Pharmaceutical Sciences‚ Kwame Nkrumah University of Science and Technology‚ Kumasi‚ Ghana ABSTRACT High Performance Liquid Chromatography has been used to evolve an analytical procedure for the evaluation of the content of paracetamol in the bulk‚ dosage
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It was concluded that the product created was paracetamol when a thin layer chromatography test was performed and observed under ultraviolet light (which is discussed further down the page). An unknown substance was treated with acetic anhydrate and resulted with paracetamol. A compound that behaves in this matter is 4-aminophenol and is widespread in the industrial production of this drug. Upon these observations was the build up of “Chemical A” decided. When 4-aminophenol is t treated with
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fake versions containing either the wrong ingredients or inaccuracy of the active ingredient which can cause toxicity issues in patients using these products. The aim of this experiment is to find if the percentage composition of the label (50% paracetamol‚ 40% aspirin and 10% sucrose) matches that of the percentage composition of the powder by following 10% ranges of each component in the powder. I am going to do this via a number of methods including vacuum filtration‚ heating‚ extraction and evaporation
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TRADE NAME | STRENGTH | NOS. | REMARKS ( CONTACT FOR QUERY/ DOUBTS | | ENT | | | | CONTACT DR J. SHROFF 09824299422 | 1 | TAB CEFADROXYL | DAX500 | 500mg | 840 | | 2 | TAB CEFADROXYL | DAX250 | 250mg | 400 | | 3 | TAB DICLOFENAC + PARACETAMOL | - | - | - | N/A(AVAILABLE SEPARATELY) | 4 | TAB DIOMINIC DA/SIMILAR DECONGESTENT | - | - | - | AVAILABLE SEPARATELY | 5 | CIPROFLOXACIN &DEXAMETHASONE EAR DROPS | - | - | 60 | | 6 | GENTAMYCIN EAR DROPS | - | - | 60 | | 7 | OTRIVIN
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to moderate pain such as headaches‚ migraines‚ or for lowering a high temperature or relieving aches or discomfort associated with colds and flu. Panadol contains around 500 grams of Paracetamol‚ which is a mild and safe pain reliever. Due to its composition of Paracetamol‚ the pain is relieved because the paracetamol reduces the production of prostaglandins in the brain and spinal cord. Prostaglandins are produced when injury or certain diseases affect the body‚ and so they give off warning to the
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Chemicals SAMPLE NAME: Paracetamol Tablets ANALYSIS REQUIRED: Paracetamol CLAIM: Each tablet contains 500mg Paracetamol. THEORY: Paracetamol IUPAC Name: N-(4-hydroxyphenyl)ethanamide N-(4-hydroxyphenyl)acetamide Molecular Formula: C8H9NO2 Chemical Structure: Paracetamol INN or acetaminophen USAN is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in
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1. Start off by weighing two paracetamol tablets using some accurate scales. Record the mass down (1.15g). This had to be as accurate and precise as we could get it so we had the correct weight to start the experiment. Without this then the results we found at the end would not be accurate. A problem that could be faced with this is that the scales may not have been fully set to zero. Also it takes time for it to fully reach its weight on the reading so you may move them too quick before the right
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covering the break or tear in the skin while it heals. Paracetamol Paracetamol (acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of action of is not known. Paracetamol is used to treat many conditions such as headache‚ muscle aches‚ arthritis‚ backache‚ toothaches‚ colds‚ and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint. Paracetamol may also be used for other purposes not listed in this medication
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the following keywords: acetaminophen‚ intravenous‚ paracetamol‚ postoperative pain‚ and analgesia. IV acetaminophen compared to oral route has shown to have a superior
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curtains were dirty and required frequent washing. Detailed questioning revealed that she thought they were yellow-green and possibly mouldy. Her prescribed medications are: * Frusemide 40 mg daily in the morning * Digoxin 250 micrograms daily * Paracetamol 500 mg‚ 1-2 tablets 4-hourly PRN * Piroxicam 20 mg at night * Mylanta suspension‚ 20 ml PRN * Coloxyl 120 mg‚ 1-2 tablets at night Critically discuss this case study in terms of the problematic nature of this patient’s pharmacological management
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