Daclizumab (Biogen Idec and Abbott Biotherapeutics Corp.) is a humanized mAb acting as a blocker of the α-subunit (CD25) of the high-affinity IL-2 receptor [19]. IL-2 is secreted by activated lymphocytes and stimulates production of other proinflammatory cytokines while it is also involved in lymphocytic proliferation. Daclizumab was initially approved for the prevention of renal allograft rejection as part of a combination regimen and evidence was progressively accumulated showing that this drug
Premium Immune system Cancer Protein
Abstract Tamoxifen‚ most commonly sold under the brand name Nolvadex‚ is the most widely used drug in the treatment of breast cancer during both early and late stages. It belongs to a class of drugs known as SERMs (Selective Estrogen Receptor Modulators). SERMs work by blocking the estrogen receptors in breast cells to prevent any binding with estrogen. It is consumed orally as a tablet or as a liquid (Anon.‚ 2017). The following paper discusses the discovery of Tamoxifen‚ its laboratory synthesis
Premium Cancer Breast cancer Oncology
Question and Answer 1. Paper reported that Olfm4 deletion induces colon adenocarcinoma in APCmin mice‚ so why after miR-34 deletion‚ olfm4 positive stem cell number was increased and tumor incidence was also increased? Their research was working on the colon tumorigenesis‚ but we are working on the small intestine. Also in our model‚ colon tumor is very rare‚ could because of different genetic background. The function of Olfm4 may be also tissue specific. 2. Do these changes caused by the genetic
Premium Immune system Cancer Oncology
Quinazolines are the class of chemical compounds that are pharmacologically important as therapeutic agents. They are utilized as drugs and employed in cancer chemotherapy. They act by various mechanisms. Some of them act by inhibiting antifolat thymidylate syntheses‚ while some other derivatives inhibit tubulin polymerization. They were also found to inhibit the epidermal growth factor receptor (EGFR) tyrosine kinase over expression through the inhibition of autophosphorylation of EGFR. Further
Premium Cancer Oncology Chemotherapy
For the treatment of cancer most of the drugs currently available but they have limited therapeutic potential because they are very toxic‚ expensive‚ highly inappropriate action in treating cancer‚ or having so many side effects like granulocytopenia‚ agranulocytosis‚ lymphocytopenia‚ alopecia‚ carcinogenicity or secondary cancer especially leukaemias and hyperuricaemia etc. Curcumin is one such natural herbal medicine‚ derived from the extraction of dried rhizome of turmeric or Curcumin longa‚
Premium Cancer Oncology Chemotherapy
Biocon Limited 1. Assuming Biocon receives approval for BioMAb‚ should it launch the drug immediately or conduct phase 3 trials before launch? Elaborate the various elements of your action plan. Even if the Drug Controller General of India (DCGI) grants permission for BIOMAb in fall 2006‚ Biocon should still conduct phase 3 trials before launching. Both Biocon and Clinigene are new to the industry and strong reputations have yet to be developed. Therefore‚ Biocon must means make sure BIOMAb
Premium Oncology Cancer Chemotherapy
Rodriguez 1 Cristian Rodriguez Jenny Bass English A99 28 Sept. 2014 Essay #2 Definition In this day and age we are constantly changing the true meaning of certain words into our own definitions. The original meaning of these words are no longer properly used or are abused with some slang term. Even though some of these words contain double meanings‚ they should still be treated with respect. One specific word that stands out to me is “cancer.” Cancer is without a doubt‚ nothing that should be
Premium Joke Cancer Laughter
Greg F. grew up in the 1950s in a comfortable Queens household‚ an attractive and rather gifted boy who seemed destined‚ like his father‚ for a professional career—perhaps a career in song writing‚ for which he showed a precocious talent. But he grew restive‚ started questioning things‚ as a teenager in the late ’60s; started to hate the conventional life of his parents and neighbours and the cynical‚ bellicose administration of the country. . . . Increasingly he fell out with his parents and teachers;
Premium Brain tumor Cancer Oncology
As a part of the National Junior Honor Society‚ we are required to “make a difference”. There are many ways that we contribute to making a difference to a cause. For example‚ we can hold more fundraisers like car washes or even bakes sales. In my opinion‚ I would like to do these activities to help the American Cancer Society. There are different kinds of cancer‚ but they can all affect many lives. About 3‚400 people are diagnosed with cancer each day in the United States. They are left with the
Premium Cancer Oncology Chemotherapy
SIGNIFICANCE Hepatocellular carcinoma (HCC) is the second leading cause of cancer-death in the world. In 2012‚ 782‚000 people were diagnosed and 95% mortality rate makes it the sixth most common cancer [1]. HCC in early stages is usually asymptomatic. When symptoms do occur they are usually mistaken for other liver diseases. Therefore‚ early diagnosis of HCC is extremely challenging. Surgical resection and liver transplant are the best treatment options for early stage HCC (BCLC stage 0 or A [2])
Premium Cancer Oncology Metastasis