Stem cells – the cure to Cystic Fibrosis? Cystic Fibrosis is one of the UK’s most common life threatening diseases with it affecting over 9‚000 people. Statistics show that one in twenty five people in the UK carry the faulty gene‚ each week five babies are born with the disease and another two young lives are lost. Cystic Fibrosis is a genetic disorder caused by a recessive allele. It affects the internal organs‚ especially the lungs and digestive system‚ by clogging them with thick sticky mucus
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Cystic Fibrosis: What is Cystic Fibrosis: Cystic fibrosis (CF) is a lifelong hereditary/genetic disorder‚ meaning the disease can be passed on from parent to child and can be inherited. CF is not contagious. Both parents must be either a carrier or suffer from CF for the disease to be passed on however carriers show no symptoms that a suffer does. CF affects the respiratory system; mainly the lungs and some parts of the digestive and reproductive systems including the pancreas‚ liver and the vas
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Christopher Smith Miss Chiu AP Bio CF Case Study March 19‚ 2015 Questions: 1. Currently‚ scientists believe that Cystic Fibrosis is caused by a defect in the CFTR gene causes cystic fibrosis (CF). This gene makes a protein that controls the movement of salt and water in and out of your body’s cells. In people who have CF‚ the gene makes a protein that doesn’t work well. This causes thick‚ sticky mucus and very salty sweat. Every person inherits two CFTR genes—one from each parent. Children
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Cystic Fibrosis is caused by a fault in the cystic fibrosis transmembrane conductance regulator (CFTR) gene on chromosome 7 at q31.2. For CF to be expressed‚ a faulty copy of the gene must be present at both alleles; autosomal recessive. Therefore both parents must be carriers of‚ or affected by the cystic fibrosis gene (fig. 1) for the gene to be passed on. If a person has one copy of the faulty allele (are heterozygous) they are carriers of the gene and can pass this allele on; if they possess
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that encodes for a chloride channel called the cystic fibrosis transmembrane conductance regulator (CFTR). In ductal epithelial cells‚ CFTR is highly expressed and functions to transport fluid and anions into the lumen. Dysfunction of the CFTR gene leads to a decrease in luminal fluid volume and decreased pH‚ resulting in protein precipitation within the ductal lumen and loss of normal acinar cell function. Estimated gene frequency of cystic fibrosis varies in different ethnic groups with highest
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Cystic fibrosis is an inherited disease of secretory glands‚ including the glands that make mucus and sweat. "Inherited" means that the disease is passed through the genes from parents to children1‚ 2. People who have cystic fibrosis inherit two faulty cystic fibrosis genes one from each parent. The parents likely don’t have the disease themselves. Cystic fibrosis mostly affects the lungs‚ pancreas‚ liver‚ intestines‚ sinuses‚ and sex organs. Mucus is a substance made by the lining of some body tissues
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during their adulthood. Some of these mutations are harmless and can go unnoticed for your whole existence‚ while others can alter your health drastically. There are some mutations that are considered to be valuable‚ as well as a silent one which does not affect you at all. The mutations heard about most often are those that cause disease such as‚ cystic fibrosis‚ sickle cell disease‚ and Tay-Sachs disease (Genetics.) These specific diseases are both devastating and life changing. Each disease is
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Patients with Autoimmune Diseases/ Other Illness Cystic Fibrosis is a genetic disease that is passed down from both of the parents who have a copy of a defective in their DNA. There are variety of symptoms when it comes to cystic fibrosis such as: ‘Very salty-tasting skin‚ wheezing or shortness of breath‚ and male fertility ‘. There are no known cures for this genetic diseases‚ but there are treatments‚ and research that can help control this disease‚ and to possibly make a breakthrough discovery
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symptoms of cystic fibrosis. The different symptoms of cystic fibrosis include repeated infections and thick mucus secretions in the lungs‚ it affects you with wheezing‚ a chronic cough‚ bronchitis‚ asthma‚ weight loss‚ dehydration‚ and many more mainly affecting the lungs and stomach. Sufferers may also feel very fatigued easily. 2. Describe two problems associated with the presence of thick‚ sticky mucus (a) in the lungs and breathing passageways (b) in the digestive system a) The problems
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History of Cystic Fibrosis “Woe to that child which when kissed on the forehead tastes salty. He is bewitched and soon must die.” This proverb‚ dating back to European folklore in the 1700’s‚ was the diagnosis for the disease recognized today as Cystic Fibrosis (CF). In that time period the disease was usually fatal and common among infants. The excessive salt in the sweat‚ just one symptom of CF‚ made the disease identifiable. However‚ since the time of European folklore‚ various renowned scientists
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