MINIREVIEW Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics ANDREW R. HILGENBRINK‚ PHILIP S. LOW Department of Chemistry‚ Purdue University‚ West Lafayette‚ Indiana 47907 Received 25 May 2005; accepted 27 June 2005 Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jps.20457 ABSTRACT: Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its
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Overview “muscarinic receptor agonists” cholinergic agonists are drugs that act on acetylcholine receptors‚ thus causing excitation of the parasympathetic autonomic nervous system there are 2 types of acetylcholine receptors 1) NICOTINIC RECEPTORS - are receptor-mediated ion channels - 3 types RECEPTOR TYPE MUSCLE TYPE GANGLION TYPE LOCATION - neuromuscular junction - sympathetic autonomic ganglia - parasympathetic autonomic ganglia - CNS CNS TYPE - agonists of nicotinic receptors are discussed
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EVALUATION OF EFFECTS OF OVARIECTOMY AND TREATMENT WITH ESTROGEN-REPLACEMENT THERAPY OR SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERM) ON VOIDING FUNCTION AND P2X RECEPTOR EXPRESSION IN THE FEMALE RAT TABLE OF CONTENTS Abbreviations Page 6 Abstract Page 6 Study 1 Page 10 Introduction Page 10 Menopause and the overactive bladder Page 10 Estrogens for the treatment of OAB in post menopausal women Page 12 SERM and tamoxifen Page 15
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9‚ 2013 Music’s potential as a positive stimulus for the brain Music’s potential as a positive stimulus for the brain Word Count: 1190 Ioannis
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1. What is modality? Modality is concerned with expressing opinions and attitudes. Modality in general is defined similarly in many reference books. For example Quirk‚ Greenbaum‚ Leech and Svartvik (1985) claim‚ that “at its most general‚ modality may be defined as the manner in which the meaning of a clause is qualified so as to reflect the speaker’s judgment of the likelihood of the proposition it expresses being true” (p. 219). However‚ the authors deal with the term modality mainly in connection
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Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney Carlos P. Vio‚ Mariana Quiroz-Munoz‚ Catherina A. Cuevas‚ Carlos Cespedes and Nicholas R. Ferreri Am J Physiol Renal Physiol 303:F449-F457‚ 2012. First published 23 May 2012; doi: 10.1152/ajprenal.00634.2011 You might find this additional info useful... This article cites 55 articles‚ 29 of which you can access for free at: http://ajprenal.physiology.org/content/303/3/F449.full#ref-list-1 This article has been cited
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Esthesioneuroblastoma is also referred to as olfactory neuroblastoma. This inherited gene passes on to the next generation and in some instances more than one tumor develops. As an autosomal recessive disorder‚ the offspring inherits two mutated genes and two normal genes– one from each parent. In some cases‚ the parents show no signs of the disorder verifying the normal genes as dominate. Even though this is a rare condition‚ more prevalent in adults‚ heredity increases the chances of developing
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400 distinct odorant receptors Special proteins detecting different odors Complex olfactory system: Odorant receptors: identify different aromatic compounds and pheromones‚ and most dominant in ants Gustatory receptors: distinguish between different tastes and react to some pheromones Ionotropic glutamate receptors: narrowly tune to various poisonous and toxic compounds Two species will not have the same number of receptors‚ because of the difference of two species in terms of lifestyle Differences
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In 1956 M King Hubbert predicted that oil production would reach a peak level of production and then production would decline as oil became increasingly scarce. How could we tell if oil was becoming scarce and is there evidence that Hubbert was right? This essay will first attempt to identify the indicators of scarcity and then will analyse the debate surrounding Hubbert’s theory of Peak Oil (1956) and whether scarcity is the sole reason for production levels of oil peaking. Introduction M. King
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The Budget Assignment 1. Identify specific ways in which government is involved in your life and your family’s life in an economic way. While people like me make decisions that mold the economy‚ the government acts as a guide to keep that economy progressing into success. The government attempts to maintain growth‚ employment‚ and price stability. The government can also manipulate the economy to slow down or speed up by adjusting spending and tax rates. This results in a fluctuation in the employment
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