Synthesis of Acetanilide Reaction O NH2 + H3C C O O C CH3 O N C CH3 H + H3C O C OH Aniline Acetic anhydride Acetanilide Acetic acid Purpose: Acetanilide is a useful precursor to many pharmaceuticals such as acetaminophen and penicillin. Experimental Procedure. (Estimated time: 1.5 h.) Unless otherwise noted‚ all manipulations should be done in the chemical fume hood. Place 100 µL of aniline into a tared 10 X 75-mm test tube (standing in a small beaker or Erlenmeyer flask). Now add
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Recrystallization Abstract: Technical grade aniline was reacted with acetic anhydride to give acetanilide a dark brown color‚ due to the presence of impurities. Crystallization of the crude product from water was combined with decolorization with activated carbon‚ furnished pure acetanilide as white flakes‚ melting point 112-115°C‚ yield 70.3%. Experimental: 2 grams of technical grade aniline and 15ml water were placed in a 125ml Erlenmeyer flask. Then‚ 2.5ml of acetic anhydride was
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MATERIALS Sodium nitrite Conc‚ sulphuric acid aniline N‚N-dimethylaniline nitroaniline phenol naphthol pyridine pH paper beaker‚ test tubes graduated cylinder filter paper PROCEDURES A. Preparation of Diazonium Salt Since these are immediately reacted‚ they should be prepared in parallel fashion‚ i.e. one vessel per prospective reaction. Into each vessel‚ place 1 gram or NaNO2. At 0 C‚ add a solution of 50 mg aniline in 2 mL conc H2SO4. Agitate for 5 minutes and isolate the
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1. List all Functional Groups 2. What is an alkane? List its properties. 3. Write the name and formula of simple alkanes 4. Consider this compound (CH3)2CHCH2C(CH3)3. Name this. a. redraw it clearing all brackets and parentheses. b. Find the longest chain. Check from all directions. If it is not horizontal‚ rewrite the compound that so that longest chain IS horizontal. c. Number the carbons of the longest chain backwards and forwards.
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To get to aniline‚ tin metal acts as a reducing agent and is oxidized to SnCl4. The purification of crude aniline is done by distillation and extraction. Aniline can be converted to acetanilide by acetylation reaction using acetic anhydride with sodium acetate. This step protects the amine functional group from doing unwanted reactions
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by : Directorate of Education‚ Delhi SOME IMPORTANT REASONING BASED QUESTIONS OF ORGANIC CHEMISTRY 1. Chlorobenzene is less reactive than chloromethane. Ans. In chlorobenzene‚ each carbon atom of benzenering is sp2 hyridised and is electron withdrawing. Chlorine atom donates a lone pair of electron and acquire positive charge. The negative charge is delocalised on ortho and para position by resonance. C-Cl bond acquires partial double bond character and is 169 pm as compared to 17.0 pm in chloromethane
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Desquitado‚ John Carlos M. Drapesa‚ Arianne Valerie B. Escritor‚ Elisha Ellis R. Esteva Group 4 2B Medical Technology Organic Chemistry Laboratory ABSTRACT In this experiment‚ acetanilide was used as the pure organic compound. Acetylation of aniline and acetic anhydride yields the crude product or crude acetanilide. The crude acetanilide was purified by dissolving it in hot water and then the solution was cooled slowly by placing in an ice bath. The yielded crystals were pure acetanilide since
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members were asked to prepare the water bath‚ ice bath and a fluted filter paper while others were tasked to weigh the filter papers in advance so that the experiment will flow smoothly. The formation of crude acetanilide was due to the acetylation of aniline and acetic anhydride. The recrystallizing solvent dissolved the acetic acetanilide and was heated in a water bath. Crystals started to form after cooling the solutions in an ice bath. Pure acetanilide was the product after the second crystrallization
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Recrystallization is a technique used to purify organic solids. This method involves dissolving of a solute in a solvent and inciting the solute to produce a precipitate from a solution. In this experiment‚ acetic anhydride was added to the mixture of 2mL aniline and 20mL of distilled water. The mixture was cooled in an ice bath and filtered through filter paper resulting to the crude acetanilide. The pure acetanilide was then produced by the filtered solution of crude acetanilide and recrystallizing solvent
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Activity 1 Preparation of Acetanilide Abstract Recrystallization is a common method of purifying organic substances through the difference in solubility at different temperature. In this experiment‚ acetanilide was produced by acetylation of aniline with acetic anhydride. The crude acetanilide was dissolved in a solvent in a heating water bath. The solution was cooled slowly in an ice bath as crystals form out. As the compound crystallizes from the solution‚ molecules of other compounds dissolved
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