Organometallic preparation and addition to carbonyls‚ Wittig reagent preparation and Wittig rxn‚ Wolff‚ H-based nucleophile carbonyl reduction‚ imine formation‚ reductive amination (rxn only)‚ ketal/acetal formation‚ dithiane chemistry (rxn only)‚ alpha-bromination of ketones‚ -COOH properties (the trends on HW4)‚ Fischer‚ acidic/basic hydrolysis of esters/amides/nitriles‚ CH2N2‚ acid chloride formation (rxn only)‚ acid chloride rxns with esters and amides. 2 Rxn of carboxyllic acid derivatives w/organometallic
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substituted benzenes towards bromination will be determined‚ where bromine is dissolved in acetic acid. Materials and apparatus Test solutions: 0.2 M solutions in ethyl acetate: Benzene‚ chlorobenzene‚ phenol‚ nitrophenol‚ aniline and acetanilide. Measuring pipettes (5 mL) micro test tubes 0.05 M Br2 in 90% CH3COOH Pasteur pipettes 0.05 M Br2 in cyclohexane II. Schematic Diagram of the Procedure Relative Rates of Bromination Add 2 drops of 0.05 M
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EXP-10 CHEM 233L SYNTHESIS OF p-BROMOANILINE Introduction: In this experiment‚ p-bromoaniline was synthesized in three steps starting from aniline. Since the amino group of aniline is a strong activator of aromatic ring‚ direct bromination is impractical (equation 1). In order to make a desired product‚ amino group needed to be protected as the acetamide which also maintained ortho and para position but slowed down the rate of reaction (equation 2). Slow reaction rate would increase
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compound. n-heptane‚ pentene‚ benzene‚ heptanol‚ sec-butanol‚ phenol‚ acetyl chloride‚ buteraldehyde‚ benzaldehyde‚ 2-butanone‚ propanoic acid‚ sucrose‚ diethyl ether‚ butyl bromide‚ acetonitrile‚ L-alanine‚ n-amyl acetate‚ benzene sulfonyl chloride and aniline were used as test compounds. Observations were noted‚ such as changes in color and product formation. Iodine test‚ bromine test‚ Baeyer Test‚ Chloroform and aluminum chloride‚ fuming sulfuric acid‚ acetyl chloride‚ chromic acid‚ iodoform‚ Lucas’
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UNIVERSITI TEKNOLOGI MARA COURSE INFORMATION Confidential Code Course Level Credit Hours Contact Hours : : : : : CHM 556 Organic Chemistry II Degree 4 3 hr (Lecture) 3 hr (Practical) 3 Core CHM 456 Part Course Status Pre-requisite : : : Course Outcomes : Upon completion of this course‚ students should be able to: 1. Determine functional groups present in organic compounds using Infrared Spectroscopy and interpret Nuclear Magnetic Resonance spectra and relate the information to structural
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Unsaturated Hydrocarbons Unsaturated hydrocarbons Have fewer hydrogen atoms attached to the carbon chain than alkanes. Are alkenes with double bonds. Are alkynes with triple bonds. 1 Structure of Alkenes Alkenes (and alkynes) are unsaturated hydrocarbons Alkenes have one or more double bonds The two bonds in a double bond are different: - one bond is a sigma () bond; these are cylindrical in shape and are very strong - the other is a pi (π) bond; these involve sideways overlap of
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colorlessBoiling Point: 56.20CMelting Point: -95.30CDensity: 0.79 g/cm3 | Causes eye and skin irritation. May cause central nervous system depression. May cause liver and kidney damage. Causes respiratory tract irritation. Extremely flammable. | aniline | | Physical State: LiquidAppearance: oily - colorlessBoiling Point: 1840CMelting Point: -60CDensity: 1.0216 g/cm3 | Combustible. Hazardous in case of skin contact (irritant‚ permeator)‚ of eye contact (irritant)‚ of ingestion‚ of inhalation. Severe
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Which of the following is vinyl halide? (a) CH2CL2 (b) CH2= CH-Cl (c) CH = C-Cl (d) 6) What is B in R-OH + PX5 R-X +B+ HX? (a) HPOX3 (b) H3PO3 (c) POX3 (d) H3PO2 7) Which catalyst is used in preparation of bromobenzene by bromination of benzene? (a)FeBr3 (b) HBr (c) AlBr3 (d) Br2 8) By which name the reaction CH3 - Br + Ag- F CH3F + AgBr is known? (a) Grignard (b) Wurtz (c) Fitting (d) Swartz 9) What are nucleophilic reagents according to Lewis theory
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Phenol‚ also known as carbolic acid‚ is an aromatic organic compound with the molecular formula C6H5OH. It is a white crystalline solid that is volatile. The molecule consists of a phenyl group (-C6H5) bonded to a hydroxyl group (-OH). It is mildly acidic‚ but requires careful handling due to its propensity to cause chemical burns. Phenol was first extracted from coal tar‚ but today is produced on a large scale (about 7 billion kg/year) from petroleum. It is an important industrial commodity as a
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The Stereochemistry of Bromine Addition: Bromination of trans-Cinnamic Acid Pitak Chuawong Objectives 1. To perform bromination of trans-‐cinnamic acid 2. To investigate stereochemistry of bromination reaction Introduction Alkenes undergo electrophilic addition to give alkyl halides. When bromine is used as a
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