Amajala et al Journal of Drug Delivery & Therapeutics; 2012‚ 2(4)‚ 85-89 85 Available online at http://jddtonline.info RESEARCH ARTICLE METHYLATION PROFILING OF TUMOR SUPPRESSOR GENES INVOLVED IN LUNG CANCER * Krishna Chaitanya Amajala‚ Vishwanath A‚ Kaladhar DSVGK and Bhaskar Reddy I Department of Bioinformatics & Biochemistry‚ GITAM Institute of Science‚ GITAM University‚ Visakhapatnam-530045‚ Andhra Pradesh‚ India *Corresponding author’s Mail: chy2ak@gmail.com Received
Premium Cancer Lung cancer Oncology
medication blocks the conversion of testosterone to DHT resulting in lower intraprostatic levels of DHT. This process causes change in epithelial cell of the transition zone. This process leads to inhibition of prostatic growth‚ involution‚ and apoptosis. Eventually‚ prostate volume and progression of disease will be decreased. Thus‚ patients with larger prostates may achieve a greater benefit. However‚ maximal reduction in prostate volume requires 6 months of therapy. These medications include Finasteride
Premium Immune system Hypertension Cancer
Quinazolines are the class of chemical compounds that are pharmacologically important as therapeutic agents. They are utilized as drugs and employed in cancer chemotherapy. They act by various mechanisms. Some of them act by inhibiting antifolat thymidylate syntheses‚ while some other derivatives inhibit tubulin polymerization. They were also found to inhibit the epidermal growth factor receptor (EGFR) tyrosine kinase over expression through the inhibition of autophosphorylation of EGFR. Further
Premium Cancer Oncology Chemotherapy
Medicinal uses of Turmeric Root.Curcuma Root.: Uses supported by clinical data: The principal use of Rhizoma Curcumae Longae is for the treatment of acid‚ flatulent‚ or atonic dyspepsia. Uses described in pharmacopoeias and in traditional systems of medicine: Treatment of peptic ulcers‚ and pain and inflammation due to rheumatoid arthritis and of amenorrhoea‚ dysmenorrhoea‚ diarrhqea‚ epilepsy‚ pain‚ and skin diseases. Uses described in folk medicine‚ not supported by experimental
Premium Medicine Turmeric Ginger
The Cell Cycle A eukaryotic cell cannot divide into two‚ the two into four‚ etc. unless two processes alternate: doubling of its genome (DNA) in S phase (synthesis phase) of the cell cycle; halving of that genome during mitosis (M phase). The period between M and S is called G1; that between S and M is G2. So‚ the cell cycle consists of: G1 = growth and preparation of the chromosomes for replication; S = synthesis of DNA [see DNA Replication] and duplication of the centrosome; G2
Premium Chromosome Cell cycle Mitosis
the short arm of chromosome 16 or chromosome 4 respectively. Birth genes encodes for polycostin -1 and polycytin -2 ion channel‚ proteins necessary for the proper functioning of renal filtration. Improper functioning of renal filtration lead to apoptosis‚ increased fluid sections‚ disorganized surrounding extracellular fluid leading to cyst enlargement. When these cyst enlarges they begin to compress causing ischemia and the occlusion of normal tubules in the kidneys leading to progressive renal
Premium Polycystic kidney disease Kidney Nephrology
What causes cancer? Cancer is ultimately the result of cells that uncontrollably grow and do not die. Normal cells in the body follow an orderly path of growth‚ division‚ and death. Programmed cell death is called apoptosis‚ and when this process breaks down‚ cancer begins to form. Unlike regular cells‚ cancer cells do not experience programmatic death and instead continue to grow and divide. This leads to a mass of abnormal cells that grows out of control. What are the symptoms of cancer? Cancer
Premium Cancer Bone marrow Blood
target of those radicals in the cellular system is random. In live cells‚ DNA‚ protein and lipid are targets for the free radical’s invasion. Damaging any of those vital macromolecules in live cell affects the physiology of the cell and may lead to apoptosis and cell death. Cell injury caused by reactive oxygen species (ROS)‚ radicals such as hydroxyl radical (OH∙) and the nonradicals like hydrogen peroxide H2O2‚ appears to be a measure contributor for many aging diseases such as cancer‚ diabetes‚ cardiovascular
Premium DNA Oxygen Senescence
Pathophysiology Main article: Carcinogenesis Cancers are caused by a series of mutations. Each mutation alters the behavior of the cell somewhat. Cancer is fundamentally a disease of failure of regulation of tissue growth. In order for a normal cell to transform into a cancer cell‚ the genes which regulate cell growth and differentiation must be altered.[40] The affected genes are divided into two broad categories. Oncogenes are genes which promote cell growth and reproduction. Tumor suppressor
Premium Cancer
four phases: G1‚ S‚ G2‚ and M. During the G1 phase‚ RNAs are produced‚ proteins are synthesized and through the P53 gene (also known as the “Guardian of the Genome”)‚ cells are checked for damage and those that are found are forced to go through apoptosis where the cells are forced to “commit suicide” to prevent replication. Through the S phase‚ the DNA is duplicated and in the G2 phase‚ proteins are synthesized once more and the P53 gene checks again for mutations in the DNA. Finally during the M
Premium Cancer Oncology DNA