What Is Clostridium Difficile?
Clostridium difficile
Type of microorganisms - Harmless or even beneficial - under normal circumstances. But when something disturbs the balance of organisms in the intestines, the bacteria are harmless can grow out of control and cause infection. Bacteria shooting toxins that attack the lining of the intestines, causing a condition called Clostridium difficile colitis.
Taxonomy
Phylum Firmicutes, Class Clostridia, Order Clostridiales. Family Clostridiaceae, Genus Clostridium. Historical synonym: Bacillus difficile.
Morphology
Gram-positive, straight rods, motility is variable, have a flagella. Spores are oval, sub terminal swelling the cell.
Cultural characteristics
Colonies on blood agar plates are circular, flat or low convex, opaque, …show more content…
Difficile colonies on a blood agar plate
Ecology
Marine sediment, soil, sand, the hospital environment and the human genital tract feces of humans without diarrhea. Resistant to aminoglycosides.
Pathogenicity
Produces two large protein toxins (toxins A and B). Toxin A is lethal when given orally to hamsters but toxin B is not. Toxin A as been referred to as the enterotoxin. Toxin B is extremely cytopathic for all tissue-cultured cells tested. Pseudomembranous colitis in humans caused by overgrowth of the organism in the colon.
Symptoms
Diarrhea smelly, Fever (high temperature), Abdominal pain and Toxic mega colon (these are serious). Diarrhea is characterized by an unpleasant smell and bloodless. Abdominal pain is always present and may be severe.
Treatment
The treatment pseudomembranous colitis using either oral vancomycin or metronidazole by Alorid.achtaar medication depends on the severity of the disease and the ability to tolerate oral medications. Pfancomisan treatment has a risk for the development of enterococcus resistant to vancomycin. Li Although little absorbed from the gastrointestinal tract is still metronidazole effective treatment.
Ekhlas Mustafa Al-Brnawi
13112041 - Level 8
GB – Clinical Bacteriology I CLS
Type of microorganisms - Harmless or even beneficial - under normal circumstances. But when something disturbs the balance of organisms in the intestines, the bacteria are harmless can grow out of control and cause infection. Bacteria shooting toxins that attack the lining of the intestines, causing a condition called Clostridium difficile colitis.
Taxonomy
Phylum Firmicutes, Class Clostridia, Order Clostridiales. Family Clostridiaceae, Genus Clostridium. Historical synonym: Bacillus difficile.
Morphology
Gram-positive, straight rods, motility is variable, have a flagella. Spores are oval, sub terminal swelling the cell.
Cultural characteristics
Colonies on blood agar plates are circular, flat or low convex, opaque, …show more content…
Difficile colonies on a blood agar plate
Ecology
Marine sediment, soil, sand, the hospital environment and the human genital tract feces of humans without diarrhea. Resistant to aminoglycosides.
Pathogenicity
Produces two large protein toxins (toxins A and B). Toxin A is lethal when given orally to hamsters but toxin B is not. Toxin A as been referred to as the enterotoxin. Toxin B is extremely cytopathic for all tissue-cultured cells tested. Pseudomembranous colitis in humans caused by overgrowth of the organism in the colon.
Symptoms
Diarrhea smelly, Fever (high temperature), Abdominal pain and Toxic mega colon (these are serious). Diarrhea is characterized by an unpleasant smell and bloodless. Abdominal pain is always present and may be severe.
Treatment
The treatment pseudomembranous colitis using either oral vancomycin or metronidazole by Alorid.achtaar medication depends on the severity of the disease and the ability to tolerate oral medications. Pfancomisan treatment has a risk for the development of enterococcus resistant to vancomycin. Li Although little absorbed from the gastrointestinal tract is still metronidazole effective treatment.
Ekhlas Mustafa Al-Brnawi
13112041 - Level 8
GB – Clinical Bacteriology I CLS