Venlafaxine Hcl Case Study
The purpose of the study was to design a suitable Transdermal therapeutic system for Venlafaxine Hcl (VFH) with the objective to prolong the release to be used for controlled release drug delivery.Transdermal patches of VFH with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, theEudragit RSPO membrane in different concentrations was cast to achieve controlled release of the drug. The absence of physiochemical interactions between VFH and the polymers was confirmed by FT-IR spectroscopy. The physicochemical parameters and in-vitro drug release studies of formulations were performed and data of optimised formulation was fitted to various kinetic models. The results indicated that suitable tri-layered transdermal patches of VFH with controlled drug release
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chemicals Ltd; HPMC E50 cps and Eudragit RSPO were obtained as gift samples from Reddy’s laboratories. All other chemicals used were of analytical grade.
Methods:
Pre-formulation studies:
It is one of the important prerequisite in development of any drug delivery system. Pre-formulation studies were performed on the drug, which include melting point determination, partition coefficient and compatibility studies.
Standard graph of Venlafaxine Hcl in phosphate buffer pH 6.8:
Standard stock solution of Venlafaxine (1mg/ml) was prepared by dissolving 100mg of VFH in 100ml of phosphate buffer pH 6.8. Diluting the standard stock solution with phosphate buffer pH 6.8, solution of 100 µg/ml concentration was prepared. From this solution, dilutions were made with phosphate buffer pH 6.8 to get 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 µg/ml concentrations. The absorbance of these solutions were recorded in accordance with Beers’ law at λmax 225 nm against phosphate buffer pH 6.8 as blank using UV-Visible Spectrophotometer (Elico SL 164)and Standard graph of Venlafaxine was plotted (Figure 1).
Determination of Melting
chemicals Ltd; HPMC E50 cps and Eudragit RSPO were obtained as gift samples from Reddy’s laboratories. All other chemicals used were of analytical grade.
Methods:
Pre-formulation studies:
It is one of the important prerequisite in development of any drug delivery system. Pre-formulation studies were performed on the drug, which include melting point determination, partition coefficient and compatibility studies.
Standard graph of Venlafaxine Hcl in phosphate buffer pH 6.8:
Standard stock solution of Venlafaxine (1mg/ml) was prepared by dissolving 100mg of VFH in 100ml of phosphate buffer pH 6.8. Diluting the standard stock solution with phosphate buffer pH 6.8, solution of 100 µg/ml concentration was prepared. From this solution, dilutions were made with phosphate buffer pH 6.8 to get 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 µg/ml concentrations. The absorbance of these solutions were recorded in accordance with Beers’ law at λmax 225 nm against phosphate buffer pH 6.8 as blank using UV-Visible Spectrophotometer (Elico SL 164)and Standard graph of Venlafaxine was plotted (Figure 1).
Determination of Melting