Senior Science- Open Ended Investigation

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senior scienceSenior Science Assessment Task One
Written Task: Open Ended Investigation
Aim:
Compare the solubility of various forms of panadol at body temperature in different pH conditions Hypothesis
Panadol 6 will dissolve faster than any other panadol and all type of panadol will have increase solubility in acidic conditions Apparatus and Materials
* 54 alcohol swabs
* Glass thermometer
* 600mL pyrex measuring jug (heat resistant, transparent, glass, volumetric measuring instrument) * 54 heat resistant, transparent, plastic cups
* 18 Panadol 1 tablets “Panadol - Tablets” (Tablet with Potassium Sorbate Preservative) * 18 Panadol 2 tablets “Panadol – Caplets” (Capsule shaped Tablets with Hydroxybenzoate Preservatives) * 18 Panadol 3 capsules “Panadol – Gel Caps” (Capsule with Potassium Sorbate Preservative and Gelatine Coating) * 18 Panadol 4 capsules “Panadol – Mini Caps” (Capsule with Gelatine Coating) * 18 Panadol 5 tablets “Panado Rapid – Caplets” (Capsule shaped Tablet with Sodium Bicarbonate for accelerated digestion and Potassium Sorbate Preservative) * 18 Panadol 6 tablets “Panadol Rapid – Soluble” (Effervescent Tablets with Sodium Bicarbonate for accelerated digestion) * 1.8L distilled water (neutral solvent)

* 1.8L bottled lemon juice (acidic solvent)
* 1.35L cloudy ammonia (basic solvent)
* 0.45L distilled water (basic solvent dilution)
* 2 small saucepans
* Stove
* Permanent marker
Method
Neutral Solvent
1. Wipe thermometer with ethyl alcohol swab to sterilise
2. Boil 600mL distilled water in a saucepan on stove
3. Use sterilised thermometer to determine the temperature of water and allow to cool to 37⁰C 4. Label a plastic cup “Neutral Solvent, Panadol 1, Trial 1” 5. Measure 100mL of distilled 37⁰C water using measuring jug and pour into labelled cup 6. Add one Panadol 1 to plastic cup, record immediate changes to tablet and solvent 7. Record observations at intervals after immersion; 30sec, 1min, 3min, 5min, after stirring 8. Repeat steps 1-7, twice, labelling trials accordingly

9. Repeat steps 1-8 using Panadol 2, labelling trials accordingly 10. Repeat steps 1-8 using Panadol 3, labelling trials accordingly 11. Repeat steps 1-8 using Panadol 4, labelling trials accordingly 12. Repeat steps 1-8 using Panadol 5, labelling trials accordingly 13. Repeat steps 1-8 using Panadol 6, labelling trials accordingly Acidic Solvent

14. Wipe thermometer with ethyl alcohol swab to sterilise 15. Boil 600mL bottled lemon juice in second saucepan on stove 16. Use sterilised thermometer to determine the temperature of lemon juice and allow to cool to 37⁰C 17. Label a plastic cup “Acidic Solvent, Panadol 1, Trial 1” 18. Measure 100mL of 37⁰C lemon juice using measuring jug and pour into labelled cup 19. Add one Panadol 1 to plastic cup, record immediate changes to tablet and solvent 20. Record observations at intervals after immersion; 30sec, 1min, 3min, 5min, after stirring 21. Repeat steps 14-20, twice, labelling trials accordingly 22. Repeat steps 14-21 using Panadol 2, labelling trials accordingly 23. Repeat steps 14-21 using Panadol 3, labelling trials accordingly 24. Repeat steps 14-21 using Panadol 4, labelling trials accordingly 25. Repeat steps 14-21 using Panadol 5, labelling trials accordingly 26. Repeat steps 14-21 using Panadol 6, labelling trials accordingly Basic Solvent

27. Wipe thermometer with ethyl alcohol swab to sterilise 28. Boil 150mL distilled water in first saucepan on stove 29. Use sterilised thermometer to determine the temperature of water and allow to cool to 60⁰C 30. Add 450mL of cloudy ammonia to 150mL of 55⁰C water to create 600mL of cloudy ammonia solution 31. Use sterilised thermometer to determine the temperature of cloudy ammonia solution and allow to cool to 37⁰C 32. Label a plastic cup “Basic Solvent, Panadol 1, Trial 1”...
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