The Mortality of Workers with Occupational Lead Exposure
R esearch Report PP06214, version 3
June 2011
The mortality of workers with occupational lead exposure: A research proposal
John W Cherrie
Damien McElvenny
Martie van Tongeren
OUR IMPACT ON THE ENVIRONMENT
At IOM we seek to minimise our environmental impact. We produce thousands of reports every year and these consume a large quantity of paper. To minimise our impact on the environment, we prefer to only provide an electronic copy of reports, although we can provide a paper copy on request. If you have any additional requirements please let us know.
PP06214 - V3– The mortality of workers with occupational lead exposure:
A research proposal
CONTENTS
LAY SUMMARY
II
MAIN PROPOSAL
1
1
WHAT IS THE WORK WE WOULD LIKE TO DO?
1
1.1
1.2
Introduction
Specific Aims
1
1
2
WHY SHOULD THE WORK BE UNDERTAKEN?
2
3
WHO IS DOING OR HAS DONE SIMILAR WORK, AND HOW WILL
YOUR WORK ADD TO IT?
3
4
HOW DO YOU INTEND TO CARRY OUT THE WORK, AND WHY DO
YOU THINK THIS IS THE RIGHT APPROACH?
3
4.1
4.2
4.3
4.4
4.5
4.6
4.7
4.8
Introduction
The study database
Study power
Research governance
Tracing subjects
Exposure assessment
Data analysis
Limitations
3
3
4
5
6
6
8
8
5
WHAT RESOURCES WILL YOU NEED TO DO THE WORK, AND ARE
THESE RESOURCES AVAILABLE?
9
6
WHO WILL DO THE WORK, AND HOW MUCH TIME WILL EACH OF
THE PEOPLE INVOLVED DEVOTE TO IT?
9
7
HOW LONG WILL THE WORK TAKE?
10
8
HOW MUCH MONEY DO YOU NEED TO COMPLETE THE WORK?
10
9
WHEN DO YOU PLAN TO START?
10
10
REFERENCES
10
APPENDIX 1: A BRIEF REVIEW OF THE RISKS ASSOCIATED WITH LEAD
EXPOSURE
12
APPENDIX 1: A BRIEF REVIEW OF THE RISKS ASSOCIATED WITH LEAD
EXPOSURE
12
APPENDIX 2: INSTITUTE OF OCCUPATIONAL MEDICINE
21
APPENDIX 3: CVS
23
Page i of ii
PP06214 - V3– The mortality of workers with occupational lead exposure:
A research proposal
LAY
June 2011
The mortality of workers with occupational lead exposure: A research proposal
John W Cherrie
Damien McElvenny
Martie van Tongeren
OUR IMPACT ON THE ENVIRONMENT
At IOM we seek to minimise our environmental impact. We produce thousands of reports every year and these consume a large quantity of paper. To minimise our impact on the environment, we prefer to only provide an electronic copy of reports, although we can provide a paper copy on request. If you have any additional requirements please let us know.
PP06214 - V3– The mortality of workers with occupational lead exposure:
A research proposal
CONTENTS
LAY SUMMARY
II
MAIN PROPOSAL
1
1
WHAT IS THE WORK WE WOULD LIKE TO DO?
1
1.1
1.2
Introduction
Specific Aims
1
1
2
WHY SHOULD THE WORK BE UNDERTAKEN?
2
3
WHO IS DOING OR HAS DONE SIMILAR WORK, AND HOW WILL
YOUR WORK ADD TO IT?
3
4
HOW DO YOU INTEND TO CARRY OUT THE WORK, AND WHY DO
YOU THINK THIS IS THE RIGHT APPROACH?
3
4.1
4.2
4.3
4.4
4.5
4.6
4.7
4.8
Introduction
The study database
Study power
Research governance
Tracing subjects
Exposure assessment
Data analysis
Limitations
3
3
4
5
6
6
8
8
5
WHAT RESOURCES WILL YOU NEED TO DO THE WORK, AND ARE
THESE RESOURCES AVAILABLE?
9
6
WHO WILL DO THE WORK, AND HOW MUCH TIME WILL EACH OF
THE PEOPLE INVOLVED DEVOTE TO IT?
9
7
HOW LONG WILL THE WORK TAKE?
10
8
HOW MUCH MONEY DO YOU NEED TO COMPLETE THE WORK?
10
9
WHEN DO YOU PLAN TO START?
10
10
REFERENCES
10
APPENDIX 1: A BRIEF REVIEW OF THE RISKS ASSOCIATED WITH LEAD
EXPOSURE
12
APPENDIX 1: A BRIEF REVIEW OF THE RISKS ASSOCIATED WITH LEAD
EXPOSURE
12
APPENDIX 2: INSTITUTE OF OCCUPATIONAL MEDICINE
21
APPENDIX 3: CVS
23
Page i of ii
PP06214 - V3– The mortality of workers with occupational lead exposure:
A research proposal
LAY
References: (Burns & Beaumont, 1989). These data are generally linked to a more extensive visit report containing details of the factory and processes where the measurements were