The Human Genome Project

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PM 595 Project Risk Management

Course Project

The Human Genome Project

Submitted by

Rodney A. Lee

Instructor – Keith Bluestein

August 15, 2011

Table of Content

Introduction ……………………………………………………………………………….3

The Human Genome Project ……………………………………………………………..4

Decision Tree ……………………………………………………………………………..5

Decision Tree 1 ……………………………………………………………………...6

Risk Identification …………………………………………………………………...........6

Decision Tree 2 ……………………………………………………………………...10

Risk Management ………………………………………………………………………...14

Risks Assessment for Decision Trees 1& 2 ……………………………………………...15

Potential Risks for Participants in Genetic Testing ………………………………..17

Risk Mitigation ………………………………………………………………………..….18

Risk Acceptance Strategy ……………………………………………………………..….19

Risk Avoidance Strategy ………………………………………………………………....19

Risk Optimization Strategy ………………………………………………………………19

Risk Transference Strategy …………………………………………………………….…20

Conclusion ……………………………………………………………………….…….…21

Appendix ……………………………………………………………………………….…23

Reference …………………………………………………………………………………26

Introduction

Scientist over decades have explored and mapped lands, oceans and the heaven with the

expectation of increasing man’s awareness of the environment in which we live. The Human

Genome Project (HGP) served to explore our genetic environment to make us aware of the

beneficial resources that contribute to understanding and improving our lives. The HGP

involved the discovery of the full Deoxyribonucleic Acid (DNA) complement in a single human

somatic cell. The project purpose was to sequence this sequence of DNA so that a map of it may

be produced that shows the location and arrangement of all of the base pairs present in a human

being.

The HGP initial goals were to:
* identify all the approximately 20,000-25,000 genes in human DNA * determine the sequences of the 3 billion chemical base pairs that make up human DNA * store this information in databases

* improve tools for data analysis
* transfer related technologies to the private sector
* address the ethical, legal, and social issues (ELSI) that may arise from the project. Its primary findings were to list and locate our genes: the single unit of heredity responsible for how we develop from conception, how we grow and mature, how we live, and how we die. The Human Genome Project is a phenomenal accomplishment and scientists have recently decoded the protein sequence of DNA. This poignant knowledge will affect every single facet of science, revealing an array of possibilities caused by the decoding of the human genome but it also launches complex scientific and ethical dilemmas. Genetic engineering introduces the risk of discarding human individuality in favor of a flawless prearranged archetype.

The Human Genome Project
The Human Genome Project which operated from 1990 to 2003, through great efforts from scientist in molecular biology, biochemistry, math, computer science, engineering and the health care industry. What began in 1985 as a simple campus improvement project at the University of California, Santa Cruz turned into an international scientific consortium. In the years since completion of the HGP, the human genome database has enabled the identification of a variety of genes that are associated with disease. This, in turn, has enabled more objective and accurate diagnoses in some cases even before the onset of other clinical symptoms. Association and linkage studies have identified additional genetic influences that modify the development or outcome for both rare and common diseases. The recognition that human genomes may influence everything from disease risk to physiological response to medications has led to the emergence of the concept of personalized medicine—the idea that knowledge of a patient’s entire genome sequence will...
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