Science Investigatory Project

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Guyabano and Diabetes
An article in “African Journal of Traditional Complementary and Alternative Medicine” about in 2008 have reported that a clinical study done on rats induced with diabetes mellitus then fed with guyabano (Annona Muricata Linn) extracts showed positive effects of lowering the blood sugar levels in animals. Another study reported by the same publication showed that animals with induced diabetes mellitus that consumed guyabano extract has shoed remarkable increase of antioxidants in their blood and that there is less liver damage. The findings of this laboratory animal study suggest that (guyabano) Annona muricata extract has a protective, beneficial effect on hepatic tissues subjected to STZ-induced oxidative stress, possibly by decreasing lipid peroxidation and indirectly enhancing production of insulin and endogenous antioxidants. Although the reports suggested that guyabano extracts have promising medicinal benefits for diabetes mellitus. there is no sufficient study done on its effects to humans with diabetes. http://www.ncbi.nlm.nih.gov/pubmed/20162039

Guyabano and Inflammation
In a report that was published in “International Journal of Molecular Sciences” dated 2010, Antinociceptive and anti-inflammatory activities of the ethanol extract from guyabano leaves (Annona muricata Linn) were investigated in animal models.. In a chemically induced edema to the paw of rats showed that the guyabano ethanol extract has significantly reduced the exudate volume. These results suggest that Annona muricata can be an active source of substances with antinociceptive and anti-inflammatory activities. http://www.ncbi.nlm.nih.gov/pubmed/20559502

Guyabano and Cancer
In a study published in the “ Journal of Medicinal Chemistry”, fourteen structurally diverse Annonaceous acetogenins, found in Guyabano extract were identified and tested for their ability to inhibit the growth of adriamycin resistant human mammary adenocarcinoma cells. This cell line is...
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