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SA002 Causes Of Disease In Humans

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SA002 Causes Of Disease In Humans
The causes of disease in humans.
Lifestyle
1. BIOL1 : Basis and risk factors of heart disease
2. BIOL1 : Basis of lung disease and lung function
Pathogens
3. BIOL1 : Nature of pathogens and infection
4. BIOL1 : Cholera and dehydration
5. BIOL2 : Horizontal gene transfer and antibiotic resistance
Genetics
6. BIOL1 : symptoms of lactose intolerance
7. BIOL2 : Formation of non-functional enzymes
8. BIOL5 : Risk factors for cancer, the nature of cancer, tumours suppressor and proto-oncogenes
9. BIOL5 : Mutations and disease (e.g. sickle cell anaemia (heterozygous advantage) and cystic fibrosis
10. BIOL5 : Venoms and nerve toxins and muscle control
Breadth
 Use topics from at least three modules, units 
 Used examples of three different kingdoms [shown in green] of organisms
 Used two paragraphs [shown by ] to indicate wider reading

Disease can be defined as a malfunction of body or mind that causes symptoms and has a negative impact on health. Diseases may be inherited and have a genetic component, or can be the result of pathogenic infections. Our lifestyle choice may further exacerbate the risk of contraction of disease. This essay expands on these principles to describe how disease is caused in humans.
Pathogens, such as bacteria, fungi or viruses are agents that cause disease. Pathogens cause disease by gaining entry into the host, colonise the tissues, resist the host defences and cause damage to the cells. Infection can result from the penetration of the digestive system [cholera, typhoid and dysentery] when the gut is exposed to contaminated food and water; or the gas exchange system [tuberculosis, influenza, bronchitis] where the lungs and airways are infected by breathing contaminated air. Once the pathogen has colonised the host tissues it may cause recognisable symptoms by damaging the cells or by releasing toxins. Host tissues may be overwhelmed by sheer numbers of cells or, in the case of viruses, pathogens invade host cells and

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