List And Describe The Four Factors That Affect The Rate Of Drug Distribution

1/ List and describe the four factors that affect the rate of drug distribution. The four factors that affect the rate of drug distribution are absorption, metabolism, distribution, and excretion. a. Absorption is the movement of a drug from its site of administration into the blood. Most drugs are absorbed by passive absorption but some drugs need carrier-mediated transport. Example: Acidic drugs such as aspirin will be better absorbed in the stomach whereas basic drug like morphine will be absorbed better in the intestine b. Metabolism: It is the process of transformation of a drug within the body to make it more hydrophilic so that it can be excreted out from the body by the kidneys. This needs to be done since drugs and chemicals are foreign substances in our body. Example: Some enzymes are highly specific and will breakdown only compounds that they recognize for glucose dehydrogenase. c. Distribution: Distribution is the movement of drugs throughout the body. Determined by the blood flow to the tissues, it is an
2/ How will you explain an adverse effect on a patient? When a patient has an adverse effect on the drug that most patient medication allergies without including the type of reaction could lead to unnecessarily withholding the medication to which the patient has actually experienced a non–life-threatening drug reaction, not an allergic reaction. If these patients are asked about their allergy symptoms, physicians say that the drug makes them drowsy or nauseated, which clearly does not indicate an allergy. Sometimes the allergy can mislead practitioners and result in unnecessary modification of treatment. How is different than side