However, a defect in aldolase A would not cause as severe of a disease as defects in aldolase B since the products and substrates of aldolase A can be metabolized or broken down by other enzymes. Thus, a buildup of a substance would not occur and there would be no severe metabolic disease symptoms.
As previously discussed, accumulation of fructose 1-phosphate is the main cause for the severe symptoms of heredity fructose intolerance. Fructose 1-phosphate is made from the phosphorylation of fructose. The enzyme that catalyzes this phosphorylation is fructokinase. That is, fructokinase catalyzes the phosphorylation of fructose to fructose 1-phosphate. Therefore, it is logical to conclude that inhibition of liver fructokinase results in decreased levels of fructose 1-phosphate. This would seem to lead to alleviation of the severe symptoms of heredity fructose