Jordan P. Santos
Comparison of Total Leaf Polyphenols and Gallic Acid
Content of Camellia sinensis and the Fifteen
Most Speciose-Genera in Philippine Flora
Background of the Study
In 2008, cancer topped the list of disease-causing deaths summing a count of 7.6 million deaths around the globe which is 13% of all recorded mortalities according to the World Health Organization. The complicated nature of the disease itself was responsible for its increasing capability to inflict deaths and therefore cause higher mortality rates worldwide. In the quest to cure cancer, different modalities were developed by oncologists namely surgery, irradiation, chemotherapy, endocrine therapy, gene therapy, and organ transplantation (Bast et al., 2000). However, utilization of these methods of therapeutic approaches did not give a complete response on killing all cancer cells and produced adverse effects on normal healthy cells. Multimodal therapies and precision instruments were developed to further increase efficiency of the treatment yet no method was known to provide a definite and complete cure without side effects. On the late 20th century, polyphenols have come to the industry of healthcare and beauty. Furthermore, various studies on these natural substances proved that they can act as antioxidants and, on the latter years, as potential chemopreventive and ultimately chemotherapeutic agents (Di Domenico et al., 2011). As research and science pondered to know more about polyphenols, these substances were further characterized to smaller groups wherein catechins and gallic acids belong. Catechins are polyphenols found mostly on green tea that act as chemotherapeutic agents as they kill cancer cells in vitro (Brown, 1999). Gallic acid on the other hand is hydrolysable tannin found also on plants that direct mechanisms of cell killing only to cancer cells and not on normal healthy cells (Yong Lua et al., 2010). A plant known to contain the highest levels of catechins and gallic acid is Camellia sinensis (L.) Kuntze (Brown, 1999). However, the amount of these substances in this plant is not adequate to be used industrially as a primary source of polyphenols to be utilized in chemotherapy. With the fact that polyphenols especially gallic acids have high potential to finally cure cancer, this research aims to utilize the Philippine plants as a source of these natural substances by determination and comparison of their contents with Camellia sinensis (L.) Kuntze. Statement of the Problem
Will there be a significant difference between the total leaf polyphenol and gallic acid contents of the fifteen most speciose-Genera in Philippine Flora and Camellia sinensis (L.) Kuntze? Research Objective
This research study aims to determine if there will be a significant difference between the total leaf polyphenol and gallic acid contents of the fifteen most speciose-genera in Philippine Flora and Camellia sinensis (L.) Kuntze.
Significance of the Study
The conclusions of this study shall be beneficial to oncologists as they will acquire knowledge about plants that shall be utilized for cancer treatment. Furthermore, the study shall contribute to the list of medicinal and therapeutic plants which most people in the provinces use as their primary medicine. The results of the study will be most valuable to cancer patients as efficient healthcare and appropriate treatment using polyphenols will provide them higher chances of survival. This study may also well contribute to the economy for knowledge of possible native plants that provide a source of polyphenols will be used by the people to raise farms that will facilitate growth and mass production of these plants. Scope and Delimitations
This study will focus on determining the polyphenol and gallic acid contents of only the cultivars of the 15 most-speciose genera of Philippine Flora to be conducted from April 2013 to February 2014 on local setting....
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