Commercial Aspirin Lab
Commercial Aspirin Tablet Analysis
Tuesday Evening
Intro:
The purpose of this lab was to analyze commercial aspirin tablets. To do so, the percent acetylsalicyclic acid (active ingredient) in tablets using acid-base titration was determined, the percent acetylsalicyclic acid in tablets by formation of a colored iron(III)-salicylate complex was determined using spectrometry, and then the percents from each process was compared. Acetylsalicylic acid is produced when salicylic acid and acetic anhydride react in the presence of H2SO4. Consequently, the said reaction produces acetylsalicylic acid and acetic acid. In part one of the lab, titration of a NaOH solution with an indicator and a known concentration into a solution containing …show more content…
The curve had a slope of 1246 L/mol and a maximum wavelength absorbance at 528 nm which is shown in Figure 2. This data from the standard curve could then be used in accordance with the spectrophotometer to test for absorbance and to determine the mass percent of acid within the aspirin tablet.
Table 3. Mass Percent of Acetylsalicyclic Acid in Member’s Mark Aspirin | Absorbance | Diluted Conc. (M) | Original Conc. (M) | Moles of Acid | Mass Percent | Sample 1 | .8696 | 6.975E-4 | .01395 | .003488 | 84.50% | Sample 2 | .8691 | 6.971E-4 | .01394 | .003485 | 84.50% | Sample 3 | .8717 | 6.992E-4 | .01398 | .003495 | 83.89% | Sample 4 | .8630 | 6.992E-4 | .01384 | .003460 | 84.58% | Sample 5 | .8754 | 7.022E-4 | .01404 | .003510 | 85.10% | Sample 6 | .8710 | 6.987E-4 | .01397 | .003493 | 84.70% | …show more content…
Member’s Mark aspirin claims to have 325mg of the active ingredient acetylsalicyclic acid in the tablet, accounting for roughly 86% of the entire pill. In the first part of the experiment, I experimentally found the average mass percent to be 85.5%. In the second part, the average mass percent was determined to be 84.55% with a average deviation of .25%. After examining a wavelength scan, the wavelength that appeared to have the highest absorbance was at 528nm, which can be seen by the graph scan attached. According to Beer’s Law, 528nm would hypothetically give the most accurate results. Clearly, the two experimental results are both remarkably close to the predicted value. Also, the results show that the Member’s Mark aspirin tablets are within the permissible 5% of the bottle
Tuesday Evening
Intro:
The purpose of this lab was to analyze commercial aspirin tablets. To do so, the percent acetylsalicyclic acid (active ingredient) in tablets using acid-base titration was determined, the percent acetylsalicyclic acid in tablets by formation of a colored iron(III)-salicylate complex was determined using spectrometry, and then the percents from each process was compared. Acetylsalicylic acid is produced when salicylic acid and acetic anhydride react in the presence of H2SO4. Consequently, the said reaction produces acetylsalicylic acid and acetic acid. In part one of the lab, titration of a NaOH solution with an indicator and a known concentration into a solution containing …show more content…
The curve had a slope of 1246 L/mol and a maximum wavelength absorbance at 528 nm which is shown in Figure 2. This data from the standard curve could then be used in accordance with the spectrophotometer to test for absorbance and to determine the mass percent of acid within the aspirin tablet.
Table 3. Mass Percent of Acetylsalicyclic Acid in Member’s Mark Aspirin | Absorbance | Diluted Conc. (M) | Original Conc. (M) | Moles of Acid | Mass Percent | Sample 1 | .8696 | 6.975E-4 | .01395 | .003488 | 84.50% | Sample 2 | .8691 | 6.971E-4 | .01394 | .003485 | 84.50% | Sample 3 | .8717 | 6.992E-4 | .01398 | .003495 | 83.89% | Sample 4 | .8630 | 6.992E-4 | .01384 | .003460 | 84.58% | Sample 5 | .8754 | 7.022E-4 | .01404 | .003510 | 85.10% | Sample 6 | .8710 | 6.987E-4 | .01397 | .003493 | 84.70% | …show more content…
Member’s Mark aspirin claims to have 325mg of the active ingredient acetylsalicyclic acid in the tablet, accounting for roughly 86% of the entire pill. In the first part of the experiment, I experimentally found the average mass percent to be 85.5%. In the second part, the average mass percent was determined to be 84.55% with a average deviation of .25%. After examining a wavelength scan, the wavelength that appeared to have the highest absorbance was at 528nm, which can be seen by the graph scan attached. According to Beer’s Law, 528nm would hypothetically give the most accurate results. Clearly, the two experimental results are both remarkably close to the predicted value. Also, the results show that the Member’s Mark aspirin tablets are within the permissible 5% of the bottle