Cms 441 Week 1
Blood Banking
OR
Immunohaematology
OR
Blood Transfusion
Instructor course
Dr. Abbas Alsaeed
CLS 441
Contents (CLS 441)
1. Introduction of Immunohaematology
2. ABO Blood Group System
3. The Rh Blood Group System
4. Other Blood Group System
5. Antihuman Globulin (Coombs’) Test
6. Detection and Identification of Antibodies
7. Cross Matching (Compatibility Testing)
8. Transfusion Reactions and Complications
9. Screening for Diseases Transmitted through Blood
10. The Blood Donor and Collection of Blood
11. Storage and Preservation of Blood and Components
12. Haemolytic Disease of the Newborn (HDN)
13. Autoimmune Haemolytic Anaemia (AIHA)
14. Blood Components
15. Transfusion Therapy …show more content…
Group II Discrepancy
This discrepancy is between forward and reverse grouping owing to weak or missing antigens. This is a quite uncommon type of discrepancy. Some of the common causes in this group are:
• Subgroups may be present
• Weak expression of A or B antigens in cases of leukemias or occasionally Hodgkin’s disease
• Acquired B antigen; this is suspected when the group appears AB but the serum contains anti-B. A1 cells are notorious for such type of expression. This phenomenon is frequently encountered in patients of carcinoma colon and rectum.
Group III Discrepancy
This discrepancy between forward and reverse groupingusually occurs due to abnormalities of plasma proteins. Thecommon conditions resulting in this type of discrepancy are:
• Multiple myeloma
• Waldenstrom’s macroglobulinemia
• Other plasma cell dyscrasias
Group IV Discrepancy
This discrepancy may have miscellaneous problems. Some of the common causes are: • Polyagglutination: This is the spontaneous agglutination of red cells by most normal adult sera. It can occur owing to exposure of a hidden erythrocyte antigen called “T antigen” due to bacterial or viral contamination. Few characteristics of this reaction
OR
Immunohaematology
OR
Blood Transfusion
Instructor course
Dr. Abbas Alsaeed
CLS 441
Contents (CLS 441)
1. Introduction of Immunohaematology
2. ABO Blood Group System
3. The Rh Blood Group System
4. Other Blood Group System
5. Antihuman Globulin (Coombs’) Test
6. Detection and Identification of Antibodies
7. Cross Matching (Compatibility Testing)
8. Transfusion Reactions and Complications
9. Screening for Diseases Transmitted through Blood
10. The Blood Donor and Collection of Blood
11. Storage and Preservation of Blood and Components
12. Haemolytic Disease of the Newborn (HDN)
13. Autoimmune Haemolytic Anaemia (AIHA)
14. Blood Components
15. Transfusion Therapy …show more content…
Group II Discrepancy
This discrepancy is between forward and reverse grouping owing to weak or missing antigens. This is a quite uncommon type of discrepancy. Some of the common causes in this group are:
• Subgroups may be present
• Weak expression of A or B antigens in cases of leukemias or occasionally Hodgkin’s disease
• Acquired B antigen; this is suspected when the group appears AB but the serum contains anti-B. A1 cells are notorious for such type of expression. This phenomenon is frequently encountered in patients of carcinoma colon and rectum.
Group III Discrepancy
This discrepancy between forward and reverse groupingusually occurs due to abnormalities of plasma proteins. Thecommon conditions resulting in this type of discrepancy are:
• Multiple myeloma
• Waldenstrom’s macroglobulinemia
• Other plasma cell dyscrasias
Group IV Discrepancy
This discrepancy may have miscellaneous problems. Some of the common causes are: • Polyagglutination: This is the spontaneous agglutination of red cells by most normal adult sera. It can occur owing to exposure of a hidden erythrocyte antigen called “T antigen” due to bacterial or viral contamination. Few characteristics of this reaction