Annotated Bibliography On Pytomedicine
NIH Public Access
Author Manuscript
Phytomedicine. Author manuscript; available in PMC 2013 December 15.
Published in final edited form as:
Phytomedicine. 2012 December 15; 20(1): 17–23. doi:10.1016/j.phymed.2012.09.017.
The Chinese Pueraria root extract (Pueraria lobota) ameliorates impaired glucose and lipid metabolism in obese mice
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Jeevan K. Prasaina, Ning Pengb, Rajani Rajbhandaria, and J. Michael Wyssb,* aDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham,
Birmingham, AL 35294, USA bDepartment of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Abstract
$watermark-text
The incidence of type 2 diabetes and metabolic disease is rapidly increasing, …show more content…
Page 7
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administration (Prasain et al., 2007, Prasain et al., 2004). Thereafter, the circulating puerarin is rapidly excreted in the urine and only low concentrations of daidzein and equal remain present in the blood. In our previous studies in rats, oral administration of puerarin produced a high concentration of intact puerarin in the urine collected within the first 4 h (Prasain et al., 2004). This indicates that puerarin is rapidly absorbed in the small intestines. After 4 h, the concentration of intact puerarin decreased substantially while the concentrations of daidzein, dihydrodaidzein, and equol were increased in the urine samples. By 72 h equol was the most abundant metabolite in the urine (Prasain et al., 2004). Since equol is produced after reductive metabolism of daidzeinby intestinal bacteria, these results suggest that puerarin is slowly hydrolyzed to daidzein by bacterial enzymes in the large intestine and subsequently reduced to dihydrodaidzein and equol. Chronic feeding studies with puerarin versus kudzu root extract will assist in understanding which of these mechanisms is primarily responsible for the high circulating equol concentrations in mice. Further, …show more content…
Clin Chim Acta. 2004; 347:121–128. [PubMed: 15313149]
Meezan E, Meezan EM, Jones K, Moore R, Barnes S, Prasain JK. Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. J Agric Food Chem. 2005; 53:8760–8767. [PubMed:
16248582]
Miura A, Kajita K, Ishizawa M, et al. Inhibitory effect of ceramide on insulin-induced protein kinase
Czeta translocation in rat adipocytes. Metabolism. 2003; 52:19–24. [PubMed: 12524657]
Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem. 1997; 272:10585–10593. [PubMed: 9099705]
Oestvang J, Anthonsen MW, Johansen B. LysoPC and PAF Trigger Arachidonic Acid Release by
Divergent Signaling Mechanisms in Monocytes. J Lipids. 2011:532145–532156. [PubMed:
21912747]
Holland WL, Scherer PE. PAQ receptors: a counteracting force to ceramides? Mol Pharmacology.
2009; 75:740–3.
Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2003; 163:427–436. [PubMed:
Author Manuscript
Phytomedicine. Author manuscript; available in PMC 2013 December 15.
Published in final edited form as:
Phytomedicine. 2012 December 15; 20(1): 17–23. doi:10.1016/j.phymed.2012.09.017.
The Chinese Pueraria root extract (Pueraria lobota) ameliorates impaired glucose and lipid metabolism in obese mice
$watermark-text
Jeevan K. Prasaina, Ning Pengb, Rajani Rajbhandaria, and J. Michael Wyssb,* aDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham,
Birmingham, AL 35294, USA bDepartment of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Abstract
$watermark-text
The incidence of type 2 diabetes and metabolic disease is rapidly increasing, …show more content…
Page 7
$watermark-text
administration (Prasain et al., 2007, Prasain et al., 2004). Thereafter, the circulating puerarin is rapidly excreted in the urine and only low concentrations of daidzein and equal remain present in the blood. In our previous studies in rats, oral administration of puerarin produced a high concentration of intact puerarin in the urine collected within the first 4 h (Prasain et al., 2004). This indicates that puerarin is rapidly absorbed in the small intestines. After 4 h, the concentration of intact puerarin decreased substantially while the concentrations of daidzein, dihydrodaidzein, and equol were increased in the urine samples. By 72 h equol was the most abundant metabolite in the urine (Prasain et al., 2004). Since equol is produced after reductive metabolism of daidzeinby intestinal bacteria, these results suggest that puerarin is slowly hydrolyzed to daidzein by bacterial enzymes in the large intestine and subsequently reduced to dihydrodaidzein and equol. Chronic feeding studies with puerarin versus kudzu root extract will assist in understanding which of these mechanisms is primarily responsible for the high circulating equol concentrations in mice. Further, …show more content…
Clin Chim Acta. 2004; 347:121–128. [PubMed: 15313149]
Meezan E, Meezan EM, Jones K, Moore R, Barnes S, Prasain JK. Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. J Agric Food Chem. 2005; 53:8760–8767. [PubMed:
16248582]
Miura A, Kajita K, Ishizawa M, et al. Inhibitory effect of ceramide on insulin-induced protein kinase
Czeta translocation in rat adipocytes. Metabolism. 2003; 52:19–24. [PubMed: 12524657]
Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem. 1997; 272:10585–10593. [PubMed: 9099705]
Oestvang J, Anthonsen MW, Johansen B. LysoPC and PAF Trigger Arachidonic Acid Release by
Divergent Signaling Mechanisms in Monocytes. J Lipids. 2011:532145–532156. [PubMed:
21912747]
Holland WL, Scherer PE. PAQ receptors: a counteracting force to ceramides? Mol Pharmacology.
2009; 75:740–3.
Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2003; 163:427–436. [PubMed: