Acetaminophen: Crystal and Crude Product
Acetaminophen
Data:
p-aminophenol: 0.150g
Weight of crude acetaminophen 0.122g
Weight of purified acetaminophen 0.060g
Weight of crystallized acetaminophen 0.028g
Melting point range for dried crude product 166.8-167.6°C
Melting point range for final crystallized product 166.1-169.8°C
Melting point range for pure Acetaminophen 169.5-171°C
Results:
After first isolation of crude acetaminophen, 1.22g of light, brown shiny, fine Crestline solid emulated, which demonstrated slight less than 0.030g of product was lost from original 0.150g of p-aminophenol. The melting point range of crude acetaminophen ranged from 166.8-167.6°C, when compare to the known melting point of pure acetaminophen which ranged from 169.5-171°C, is slightly depressed. After decolonization of crude acetaminophen 0.060g of a very light tan/pink almost white, fine, shiny crystalline purified acetaminophen was recovered. Significant amount was lost; slightly over half was lost from 0.122g crude acetaminophen. Purified acetaminophen resulted in a much lighter coloration than the crude acetaminophen. Purified acetaminophen was slightly light tan/pink nearly white, whereas crude acetaminophen was light brown. After crystallization of acetaminophen, 0.028g of whiter, shiny, fine crystals resulted with no apparent odor. Slightly less than half of product was lost from 0.060g purified acetaminophen that was crystallized and about 0.122g was lost from the original 0.150g of p-aminophenol started with. The melting point range of the crystallized acetaminophen (166.1-169.8 °C when compared to the known melting point range of pure acetaminophen at 169.5-171°C is clearly depressed and elongated.
169.5-171°C
Calculations:
% yield of crude product: x = 0.207g crude acetaminophen x 100 = 58.7%
% yield of crystallized (final) product x = 0.207g crude acetaminophen x 100 = 13.5%
Observations:
Data:
p-aminophenol: 0.150g
Weight of crude acetaminophen 0.122g
Weight of purified acetaminophen 0.060g
Weight of crystallized acetaminophen 0.028g
Melting point range for dried crude product 166.8-167.6°C
Melting point range for final crystallized product 166.1-169.8°C
Melting point range for pure Acetaminophen 169.5-171°C
Results:
After first isolation of crude acetaminophen, 1.22g of light, brown shiny, fine Crestline solid emulated, which demonstrated slight less than 0.030g of product was lost from original 0.150g of p-aminophenol. The melting point range of crude acetaminophen ranged from 166.8-167.6°C, when compare to the known melting point of pure acetaminophen which ranged from 169.5-171°C, is slightly depressed. After decolonization of crude acetaminophen 0.060g of a very light tan/pink almost white, fine, shiny crystalline purified acetaminophen was recovered. Significant amount was lost; slightly over half was lost from 0.122g crude acetaminophen. Purified acetaminophen resulted in a much lighter coloration than the crude acetaminophen. Purified acetaminophen was slightly light tan/pink nearly white, whereas crude acetaminophen was light brown. After crystallization of acetaminophen, 0.028g of whiter, shiny, fine crystals resulted with no apparent odor. Slightly less than half of product was lost from 0.060g purified acetaminophen that was crystallized and about 0.122g was lost from the original 0.150g of p-aminophenol started with. The melting point range of the crystallized acetaminophen (166.1-169.8 °C when compared to the known melting point range of pure acetaminophen at 169.5-171°C is clearly depressed and elongated.
169.5-171°C
Calculations:
% yield of crude product: x = 0.207g crude acetaminophen x 100 = 58.7%
% yield of crystallized (final) product x = 0.207g crude acetaminophen x 100 = 13.5%
Observations: