Preview

Titration Lab

Better Essays
Open Document
Open Document
2835 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Titration Lab
The Mass of Acetylsalicylic Acid in Aspirin

-------------------------------------------------
Purpose
The purpose of the lab is to determine the mass of the ‘active ingredient’ in a commercial ASA tablet.
-------------------------------------------------

-------------------------------------------------
Introduction
There are three main theories surrounding acids and bases including the Arrhenius, Bronsted-Lowry, and Lewis theories. The Arrhenius theory of acids and bases states that acids produce hydrogen ions (H+) in solution while bases produce hydroxide ions (OH-) in solution. Arrhenius was able to determine his theory based on his prior knowledge of the behaviour of substances in aqueous solution. Arrhenius went further to describe strong acids as a strong electrolyte that was able to ionize completely in order to give hydrogen ions in aqueous solutions. However weak acids can only ionize partially, remaining moderately in molecular form. Similarly, a strong base is also a strong electrolyte that ionizes completely to release hydroxide ions in aqueous solution while weak bases only partially ionize. The Arrhenius theory is specifically deals with acid-base reactions in water. The second theory, intends the contemporary ‘protonic’ or Brownsted-Lowry theory of acid-base behaviour. This theory states that an acid is a compound or ion that can give up a proton however a base is a compound or ion that accepts a proton. Water is amphiprotic because water can give up and accept proton depending on the reaction. Water gives up a proton to form hydroxide ions (OH-) but water accepts a proton to form hydronium ion (H3O+). The Bronsted-Lowry theory is just an addition to the Arrhenius theory in term of all Arrhenius bases that are sources of hydroxide will accept protons. Bronsted-Lowry theory also coincides with the ability for ammonia and amines to accept protons to form ammonium ions and it can also be applied to reactions that involve solutions that do



Bibliography: 1. "Aspirin." Apuntes, Trabajos, Exámenes, Prácticas y Otros documentos. N.p., n.d. Web. 28 May 2010. <http://html.rincondelvago.com/aspirin_1.html>. 2. "Neutralization reaction." Connexions - Sharing Knowledge and Building Communities. N.p., n.d. Web. 28 May 2010. <http://cnx.org/content/m17138/latest/>. 3. "Phenolphthalein." Digipac Microcomputer Software. N.p., n.d. Web. 28 May 2010. <http://digipac.ca/chemical/equilibrium/phenolpthalein.htm>. 4. "Titration." An Introduction to Chemistry - Bishop. N.p., n.d. Web. 28 May 2010. <http://chiralpublishing.com/Bishop_Titration.htm>. 5. stander. "Acids and Bases." Chemistry and New Zealand. N.p., n.d. Web. 28 May 2010. <http://www.chemistry.co.nz/acids_and_bases.htm>.

You May Also Find These Documents Helpful

  • Better Essays

    Titration is a method, which is meant to find the concentration of either an acid or a base by adding a measured amount of it to a known volume and concentration of an acid or base1. Titration starts with a beaker or Erlenmeyer flask containing a very precise volume of the known concentration solution and a small amount of indicator, which is put underneath a burette containing the solution with unknown concentration1. Small drops of the titrant are then added to the known solution and indicator until the indicator changes which means the endpoint has been reached. Single drops of the titrant can sometimes make a permanent or temporary change in the indicator2.…

    • 2337 Words
    • 10 Pages
    Better Essays
  • Powerful Essays

    The purpose of this experiment was to perform the separation of aspirin, sucrose and an unknown analgesic, which are constituents of Panacetin using the methods of filtration, extraction, and purification…

    • 1744 Words
    • 7 Pages
    Powerful Essays
  • Good Essays

    The purpose of this experiment is to investigate the composition of compounds in Panacetin. Generally, it is made up of sucrose, aspirin and an unknown component, either acetanilide or phenacetin. SinceBy using different techniques, such as filtration, extraction, and evaporation, those three components have been isolated out, which is based on varies solubility and acid-based properties. The percentage of composition of Panacetin are also found, which is based on the mass of three dried components.…

    • 674 Words
    • 3 Pages
    Good Essays
  • Satisfactory Essays

    The Consulting Chemists Institute has been asked to analyze the drug preparation of Aspirin to find out what percentages of aspirin, sucrose, and drug preparation. The purpose of this experiment was to determine the unknown component of panacetin. Panacetin contains aspirin, sucrose, and an unknown component. Dichloromate reacts with Panacetin to produce the sucrose as an insoluble solid. Aspirin is removed from the solution by reacting with sodium bicarbonate. The aqueous layer reacts with hydrochloric acid, the unknown component can then be isolated by evaporating the solvent from the dichloromethane solution.…

    • 360 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    Classification of Acids and Bases. Acids: Strong, weak, binary, oxyacids, carboxylic acids. Strength of acids depends on structure. Bases: ionic, covalent. Strength of bases.…

    • 381 Words
    • 2 Pages
    Good Essays
  • Good Essays

    The purpose of this experiment is to investigate the composition of a simulated pharmaceutical preparation Panacetin, a proposed type of pain-killer. Panacetin is typically made up of sucrose, aspirin, and acetaminophen, but the third component in this experiment is unknown. The unknown component is suspected to be a chemical relative of acetaminophen, either acetanilide or phenacetin. Using techniques such as extraction, evaporation, and filtration, the three components will be isolated based on their solubilities and acid-base properties. The percent composition of Panacetin will also be deduced based on the masses of the three dried components; this is done to verify the composition attained is consistent with those listed on the preparations label. As a result of this investigation, my teammates and I allowed the Panacetin to undergo gravity filtration and separation techniques in order to identify whether there are any discrepancies in the components of the Panacetin. Furthermore, recrystallization and purification methods were used to determine if the unknown substance were similar in properties to either of the suspected unknown substances by comparing factors such as melting points to the chemical properties of phenactin and acetanilide. The results were as expected, based on the molecular weights and ratios of each separated chemicals, as well as the boiling point of the unknown it was determined that these ranges were close enough to indicate that the label is reasonably accurate in its composition. To add on however the identity of the unknown component differed from what the label indicated. In the end, the percentage composition attained based on our observations and yield confirmed that indeed the chemical composition of Panacetin were as indicated on the preparations label. The identity of the unknown component however suggested that the preparation did not contain acetaminophen as indicated, but instead was consistent with the chemical properties…

    • 305 Words
    • 2 Pages
    Good Essays
  • Good Essays

    Pre-Lab: Analgesic drugs are known for reducing pain, while antiseptic drugs reduce symptoms such as fevers and swelling. However, some of these drugs can reduce both illnesses. To obtain a pure compound in these drugs, the scientist needs to separate the desired compound by taking advantage of the different physical and chemical properties. Such as; different boiling points, melting points and their solubility properties. To do this a chemist can also asses the differences between acidic and basic substances when they are added to water soluble mixtures. Within this current experiment I will asses the pharmaceutical preparation of Panacetin, by using it 's solubility along with other organic molecules. We know that Panacetin is made up of sucrose, aspirin and some other unknown substance. We know the substance has to be Phenacetin or Acetanilide. To help solidify our reasoning, we need a % recovery of 8-12% sucrose, 35-45% aspirin and 45-55% unknown.…

    • 1948 Words
    • 56 Pages
    Good Essays
  • Good Essays

    The experiment involved the separation of the unknown from the Panacetin by first isolating the sucrose and the aspirin. This process was done by starting with three grams of Panacetin and adding dichloromethane to dissolve and then separating the sucrose by filter-gravity filtration. The aspirin was then separated with the help of sodium hydroxide to isolate the unknown. From the values found, we were able to find percentages of sucrose, aspirin, and the unknown in relation to what is found on the labels of these tablets.…

    • 956 Words
    • 4 Pages
    Good Essays
  • Better Essays

    To be able to understand how organic soluble compounds could be isolated from non-organic components, a chromatographic separation process was used. The objective of the analgesic drug identification is to isolate the organic compounds/ active ingredients in an unknown drug. The identity of the drug was determined through melting point, percent recover, and Rf values. The comparable data for acetaminophen from the manufacturer is 500mg of active ingredient. After conducting the experiment-extraction, distillation, and evaporation- 451mg of active ingredient. This relates to a 68.1% recovery. The melting point was between 158 and 165 degrees Celsius, which is almost ten degrees lower than the published melting point of acetaminophen. After conducting a TLC plate, the Rf value was calculated to be .4268, the same as the standard Rf.…

    • 1180 Words
    • 4 Pages
    Better Essays
  • Satisfactory Essays

    Explanation: Acids are typically proton donors, and allow their H+ ion to be donated in order to form a more compatible bond with an compound that has a larger number of atoms present. Bases are typically proton acceptors, and allow H+ to be accepted in order to complete the specific number of atoms it needs to form a stable compound.…

    • 1243 Words
    • 5 Pages
    Satisfactory Essays
  • Good Essays

    Aspirin Research Paper

    • 1199 Words
    • 5 Pages

    Aspirin has a pKa of 3.49 and a melting point of 138-140 degrees Celsius. Aspirin molecule’s are insoluble in water that is why it must be sold in a solid form, there are no liquid forms of aspirin available. Aspirin is ionised in the stomach. Aspirin is easily hydrolysed as…

    • 1199 Words
    • 5 Pages
    Good Essays
  • Good Essays

    Strong Bases Lab Report

    • 604 Words
    • 3 Pages

    Aqueous solutions of acids have a pH of less than 7. An acid has a ph containing acid or having the properties of an acid in particular, having a pH of less than 7. Acids we use eat and drink everyday are oranges and lemons. The strength of an acid refers to its ability or tendency to lose a proton. A strong acid is one that completely dissociates in water; in other words, one mole of a strong acid HA dissolves in water yielding one mole of H+ and one mole of the conjugate base, A−, and none of the protonated acid. Then the neutralization of acid is when the reaction between an acid and a base, producing a salt and neutralized base for example hydrochloric acid and sodium hydroxide form sodium chloride and water. Neutralization with a base weaker than the acid results in a weakly acidic salt. An example is the weakly acidic ammonium chloride, which is produced from the strong acid hydrogen chloride and the weak base ammonia. Conversely neutralizing a weak acid with a strong base gives a weakly basic salt sodium fluoride from hydrogen fluoride and sodium hydroxide. Acids are often used to remove rust and other corrosion from metals in a process known as pickling. They may be used as an electrolyte in a wet cell battery…

    • 604 Words
    • 3 Pages
    Good Essays
  • Satisfactory Essays

    Gr 10 Science Lab

    • 970 Words
    • 4 Pages

    An acid is a solution that has more free hydrogen ions (H + ) than hydroxyl ions (OH - ) and a pH less than 7. A base is a solution that has less free hydrogen ions (H + ) than hydroxyl ions (OH - ) and a pH of more than 7. In the late 1800s, the Swedish scientist Svante Arrhenius purposed that water can dissolve many compounds by separating them into their individual ions. Arrhenius suggested that acids are compounds that contain hydrogen and can dissolve in water to release hydrogen ions into solution. For example, hydrochloric acid (HCl) dissolves in water as follows:…

    • 970 Words
    • 4 Pages
    Satisfactory Essays
  • Good Essays

    Lab2

    • 520 Words
    • 3 Pages

    Compare and contrast acids and bases in terms of their H+ ion and OH- ion concentrations.…

    • 520 Words
    • 3 Pages
    Good Essays
  • Good Essays

    INT Task 3

    • 1084 Words
    • 5 Pages

    Acids normally are spoken of as giving a hydrogen ion to a solution while bases take one away. Every solution is generally either acidic or basic. Even tap water can be either slightly acidic or basic due to the natural elements like calcium or magnesium that are often naturally found in it (How Can You Tell If Something Is An Acid Or A Base, 2007).…

    • 1084 Words
    • 5 Pages
    Good Essays