2a Infrared and Analgesic Drug ID 2
2a: Infrared Spectroscopy and Analgesic Drug Identification
Abstract:
To be able to understand how organic soluble compounds could be isolated from non-organic components, a chromatographic separation process was used. The objective of the analgesic drug identification is to isolate the organic compounds/ active ingredients in an unknown drug. The identity of the drug was determined through melting point, percent recover, and Rf values. The comparable data for acetaminophen from the manufacturer is 500mg of active ingredient. After conducting the experiment-extraction, distillation, and evaporation- 451mg of active ingredient. This relates to a 68.1% recovery. The melting point was between 158 and 165 degrees Celsius, which is almost ten degrees lower than the published melting point of acetaminophen. After conducting a TLC plate, the Rf value was calculated to be .4268, the same as the standard Rf.
Introduction:
The purpose of this lab was to identify an analgesic drug and to understand how to interpret infrared spectroscopy. The lab consisted of several steps, which include extraction, distillation and filtration. Based on the active ingredient crystals that were obtained at the end of filtration, the melting point was found. The active ingredient percent recovery was calculated and compared to the manufacturers claims. Next, the Rf value of the active ingredients were found through a TLC plate and compared to the standard of the drug. From these processes, the understanding of how organic compounds can be isolated and identified was possible. Although the infrared spectroscopy was not completed, the understanding and matching of structures with their proper IR spectra was still necessary. The main functional group peaks were used to distinguish several IR spectrums; these peaks mostly occur between 1600-4000 cm^-1.
Experimental Procedure:
A water bath was heated to about 70 degrees Celsius. One unknown tablet was weighed and then crushed
Abstract:
To be able to understand how organic soluble compounds could be isolated from non-organic components, a chromatographic separation process was used. The objective of the analgesic drug identification is to isolate the organic compounds/ active ingredients in an unknown drug. The identity of the drug was determined through melting point, percent recover, and Rf values. The comparable data for acetaminophen from the manufacturer is 500mg of active ingredient. After conducting the experiment-extraction, distillation, and evaporation- 451mg of active ingredient. This relates to a 68.1% recovery. The melting point was between 158 and 165 degrees Celsius, which is almost ten degrees lower than the published melting point of acetaminophen. After conducting a TLC plate, the Rf value was calculated to be .4268, the same as the standard Rf.
Introduction:
The purpose of this lab was to identify an analgesic drug and to understand how to interpret infrared spectroscopy. The lab consisted of several steps, which include extraction, distillation and filtration. Based on the active ingredient crystals that were obtained at the end of filtration, the melting point was found. The active ingredient percent recovery was calculated and compared to the manufacturers claims. Next, the Rf value of the active ingredients were found through a TLC plate and compared to the standard of the drug. From these processes, the understanding of how organic compounds can be isolated and identified was possible. Although the infrared spectroscopy was not completed, the understanding and matching of structures with their proper IR spectra was still necessary. The main functional group peaks were used to distinguish several IR spectrums; these peaks mostly occur between 1600-4000 cm^-1.
Experimental Procedure:
A water bath was heated to about 70 degrees Celsius. One unknown tablet was weighed and then crushed
References: Padias, A. (2011). Making the connections (2nd ed., pp. 128-133). Hayden mcneil. Padias, A. (2014). Organic chemistry laboratory manual (5th ed., pp. 9-13). Hayden-mcneil.