Preview

research papers

Powerful Essays
Open Document
Open Document
9303 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
research papers
Nutrigenomics – An emerging field of science and technology unrevealing inter-relationships between nutrients and human genome using modern tools such as Transcriptomics, Metabolomics, Epigenomics and Proteomics

By
Raffia Siddique, Hafsa Iftikhar, Rabia Ejaz, Tahira Karim

List of contents
Introduction to Nutrigenomics
Emerging faces of nutrition, nutrigenomics and nutrigenetics
Experimental Approaches and Technologies used in Nutrigenomics
Metabolomics-newest tool for Nutrigenomics
Epigenomics has relation in Nutrigenomics
The importance of single nucleotide polymorphisms
Transcriptomics - Nutrigenomics interrelationship
Transcriptomics and micro-array technology
Proteomics
Proteomic technologies
Biomarkers
Effects of different nutrients on human genome
Elements present in food cause potential damage to human genome
Coffee and cigarettes combat rare liver diseases
Nutrigenomics and Ethical control
Looking forward to things which can resolve the ethical , social, legal issues
Conclusion and future perspective

Nutrigenomics – An emerging field of science and technology unrevealing inter-relationships between nutrients and human genome using modern tools such as Transcriptomics, Metabolomics, Epigenomics and Proteomic
Hafsa Iftikhar, Raffia Siddique, Rabia Ejaz, Tahira Karim and Dr.Alvina-The supervisor
National University of Sciences and Technology
Raffiasiddique_93@hotmail.com,
tahira.karim93@yahoo.com, rabiaejaz28@hotmail.com, hafsaiftikhar3@gmail.com

Abstract
Nutrigenomics is emerging field in 20th century, as the old maxim “we are what we eat”. Nutrition and genetics both are play significant role in the maintenance of human health as well as the development of lethal diseases. Genetic variations toward dietary response and the nutrients response in gene expression can also be explored by nutrigenetics and nutrigenomics According to different research studies nutrients is also having the



References: ANDERSEN, I. M., TENGESDAL, G., LIE, B. A., BOBERG, K. M., KARLSEN, T. H. & HOV, J. R. 2013. Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. BAXTER, A. J., COYNE, T. & MCCLINTOCK, C. 2006. Dietary patterns and metabolic syndrome--a review of epidemiologic evidence. Asia Pac J Clin Nutr, 15, 134-42. BLUHER, M., WILSON-FRITCH, L., LESZYK, J., LAUSTSEN, P. G., CORVERA, S. & KAHN, C. R. 2004. Role of insulin action and cell size on protein expression patterns in adipocytes. Journal of Biological Chemistry, 279, 31902-31909. BOUCHARD, C. & ORDOVAS, J. M. 2012. Fundamentals of Nutrigenetics and Nutrigenomics. Recent Advances in Nutrigenetics and Nutrigenomics, 108, 1-15. CASTLE, D. & RIES, N. M. 2007. Ethical, legal and social issues in nutrigenomics: the challenges of regulating service delivery and building health professional capacity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 622, 138-143. CHAKRAVARTI, A. 2001. To a future of genetic medicine. Nature, 409, 822-3. CORBIN, K. D. & ZEISEL, S. H. 2012. The Nutrigenetics and Nutrigenomics of the Dietary Requirement for Choline. Recent Advances in Nutrigenetics and Nutrigenomics, 108, 159-177. CORDERO, P., CAMPION, J., MILAGRO, F. I., MARZO, F. & MARTINEZ, J. A. 2008a. Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes. Lipids in Health and Disease, 7. CORDERO, P., CAMPION, J., MILAGRO, F. I., MARZO, F. & MARTINEZ, J. A. 2008b. Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes. Lipids Health Dis, 7, 49. CORNELIS, M. C., EL-SOHEMY, A., KABAGAMBE, E. K. & CAMPOS, H. 2006. Coffee, CYP1A2 genotype, and risk of myocardial infarction. Jama-Journal of the American Medical Association, 295, 1135-1141. DAVIS, C. D. & MILNER, J. 2004. Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 551, 51-64. DE GRAAF, A. A., FREIDIG, A. P., DE ROOS, B., JAMSHIDI, N., HEINEMANN, M., RULLMANN, J. A. C., HALL, K. D., ADIELS, M. & VAN OMMEN, B. 2009. Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology. Plos Computational Biology, 5. FRAZER, K. A., MURRAY, S. S., SCHORK, N. J. & TOPOL, E. J. 2009. Human genetic variation and its contribution to complex traits. Nature Reviews Genetics, 10, 241-251. GARCIA-BAILO, B., TOGURI, C., ENY, K. M. & EL-SOHEMY, A. 2009. Genetic variation in taste and its influence on food selection. OMICS, 13, 69-80. HINE, R. J., SRIVASTAVA, S., MILNER, J. A. & ROSS, S. A. 2003. Nutritional links to plausible mechanisms underlying pancreatic cancer: a conference report. Pancreas, 27, 356-66. JONES, K. T. & ASHRAFI, K. 2009. Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Disease Models & Mechanisms, 2, 224-229. KNOWLES, L. M. & MILNER, J. A. 2003. Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells. Journal of Nutrition, 133, 2901-2906. KUSSMANN, M. & AFFOLTER, M. 2009. Proteomics at the center of nutrigenomics: Comprehensive molecular understanding of dietary health effects. Nutrition, 25, 1085-1093. LENHARD, K., BOMMER, G. T., ASUTAY, S., SCHAUER, R., BRABLETZ, T., GOKE, B., LAMERZ, R. & KOLLIGS, F. T. 2005. Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol, 3, 142-9. MCNALLY, R. D. 2006. Acquiring new technology and surviving environmental pressures. Radiol Technol, 77, 191-9. MEMELINK, J. 2004. Putting the opium in poppy to sleep. Nat Biotechnol, 22, 1526-7. ORDOVAS, J. M. 2007. Genetic links between diabetes mellitus and coronary atherosclerosis. Curr Atheroscler Rep, 9, 204-10. ORDOVAS, J. M. & CORELLA, D. 2004a. Nutritional genomics. Annu Rev Genomics Hum Genet, 5, 71-118. ORDOVAS, J. M. & CORELLA, D. 2004b. Nutritional genomics. Annual Review of Genomics and Human Genetics, 5, 71-118. RENGARAJ, V., KANNUSAMY, V. & KRISHNAN, T. 2003. Cortical removal simplified by J-cannula irrigation. J Cataract Refract Surg, 29, 1852-3. RHIND, S. M. 2004. Effects of maternal nutrition on fetal and neonatal reproductive development and function. Anim Reprod Sci, 82-83, 169-81. TARPLEY, L. & VIETOR, D. M. 2007. Compartmentation of sucrose during radial transfer in mature sorghum culm. BMC Plant Biol, 7, 33. TRICHOPOULOU, A., YIANNAKOURIS, N., BAMIA, C., BENETOU, V., TRICHOPOULOS, D. & ORDOVAS, J. M. 2008. Genetic predisposition, nongenetic risk factors, and coronary infarct. Arch Intern Med, 168, 891-6. VAN OMMEN, B. & STIERUM, R. 2002. Nutrigenomics: exploiting systems biology in the nutrition and health arena. Curr Opin Biotechnol, 13, 517-21. WATKINS, S. M., HAMMOCK, B. D., NEWMAN, J. W. & GERMAN, J. B. 2001a. Individual metabolism should guide agriculture toward foods for improved health and nutrition. American Journal of Clinical Nutrition, 74, 283-286. WOODS, C. R. 2003. Lack of association of race/ethnicity and otitis media in the first 2 years of life. Clin Pediatr (Phila), 42, 687-96. WU, G., BAZER, F. W., CUDD, T. A., MEININGER, C. J. & SPENCER, T. E. 2004a. Maternal nutrition and fetal development. J Nutr, 134, 2169-72. WU, G., FANG, Y. Z., YANG, S., LUPTON, J. R. & TURNER, N. D. 2004b. Glutathione metabolism and its implications for health. J Nutr, 134, 489-92. WU, G. Y. & MEININGER, C. J. 2002. Regulation of nitric oxide synthesis by dietary factors. Annual Review of Nutrition, 22, 61-86.

You May Also Find These Documents Helpful

  • Satisfactory Essays

    Answer: For the samples they performed a 121-marker, total genome-analysis of an F2[Dahl RS]-intercross selected for contrasting parental strain susceptibilities for hyperlipidemia on regular rat diets at 6 months of age.(446)…

    • 465 Words
    • 2 Pages
    Satisfactory Essays
  • Powerful Essays

    Anatomy Case paper

    • 2241 Words
    • 9 Pages

    Blake, J. S., Munoz, K. D., & Volpe, S. (2010). Nutrition From Science to You. San Francisco, CA, USA: Pearson Education Inc. publishing as Pearson Benjamin Cummings.…

    • 2241 Words
    • 9 Pages
    Powerful Essays
  • Powerful Essays

    Sci 241 Week 5

    • 24622 Words
    • 99 Pages

    1. American Dietetic Association. America’s Food and Nutrition Attitudes and Behaviors—Nutrition and You: Trends 2000. Available online at www.findarticles.com/cf_dls/m0822/ 6_100/63910607/p1/article.jhtml/ Accessed January 13, 2004. 2. Tanphaichitr, V. Thiamin. In Modern Nutrition in Health and Disease, 9th ed. Shils, M. E., Olson, J. A., Shike, M., and Ross, A. C., eds. Baltimore: Williams & Wilkins, 1999, 381–389. 3. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B-6, Folate, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press, 1998. 4. Ford, E. S., Smith, S. J., Stroup, D. F., et al. Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int. J. Epidemiol. 31:59–70, 2002. 5. Rimm, E. B., Willett, W. C., Hu, F. B., et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279:359–364, 1998. 6. USDA Agricultural Research Service. Results from USDA’s 1994–1996 Continuing Survey of Food Intakes by Individuals and 1994–1996 Health Knowledge Survey. ARS Food Surveys Research Group, 1997. Available online at www.barc.usda.gov/bhnrc/ foodsurvey/home/html/ Accessed March 6, 2004. 7. Schaumburg, H., Kaplan, J., Windebank, A., et al. Sensory neuropathy from pyridoxine abuse. N. Engl. J. Med. 309:445–448, 1983. 8. Keniston, R. C., Nathan, P A., Leklem, J. E., and Lockwood, R. S. . Vitamin B6, vitamin C, and carpal tunnel syndrome. A cross-sectional study of 441 adults. J. Occup. Environ. Med. 38:949–959, 1997. 9. Wyatt, K. M., Dimmock, P. W., Jones, P. W., and Shaughn O’Brien, P. M. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review.…

    • 24622 Words
    • 99 Pages
    Powerful Essays
  • Powerful Essays

    Nutritional Genomics: A field of study of the relationship between genes, gene expression, and nutrition.…

    • 1835 Words
    • 8 Pages
    Powerful Essays
  • Good Essays

    unit 21 task 2

    • 1294 Words
    • 6 Pages

    Knowledge of the sources and functions of different nutrients is essential to understanding the relationship between food and health.…

    • 1294 Words
    • 6 Pages
    Good Essays
  • Satisfactory Essays

    Disparities in health and disease between various groups of the population, such as racial and ethnic groups, have increasingly become a major focus of public health research, practice, and policy. Diet is a key role to disparities in many chronic diseases and conditions. Therefore, in order to address and eventually eliminate health disparities, it is important to understand how various factors, including diet and nutrition, contribute to these disparities.…

    • 69 Words
    • 1 Page
    Satisfactory Essays
  • Powerful Essays

    Food is essential for life, our dietary intake is influenced by many different factors this includes:…

    • 1445 Words
    • 6 Pages
    Powerful Essays
  • Good Essays

    Three Days Food-Intake

    • 889 Words
    • 4 Pages

    My daily diet should contain a balance of proteins, carbohydrates (carbs), and lipids (collectively called macronutrients). According to Kirby (2011), micronutrients are substances such as vitamins, and minerals that are essential for healthy growth and developments. The body only requires small quantities of micronutrients and without them serious problems can arise. The role of each micronutrient makes proteins, carbohydrates, and lipids equally important in my diet. Proteins are important for repair and tissue growth, helps the body to make enzymes and hormones, as well as preserve lean muscle mass and is a source of energy. Carbohydrates are the body main source of energy and are easily broken down into glucose (sugar) which is used for immediate energy. They ensure that my muscles, kidneys, brain and nervous system properly functions also. All my life I have been told that fats (lipids) were bad for my health only to find out those small amounts in my diet is important for normal body function such as the absorbing of fat soluble vitamins and promotes normal growth and development. This paper is to discuss a three day food intake of proteins, carbohydrates, and lipids.…

    • 889 Words
    • 4 Pages
    Good Essays
  • Better Essays

    Marshall, J., & Bessesen, D. (03, 2002 23). Dietary fat and the development of type 2 diabetes.…

    • 1320 Words
    • 6 Pages
    Better Essays
  • Better Essays

    Hesi study

    • 2971 Words
    • 12 Pages

    Good nutrition is essential for healthy growth and development and influences disease prevention in later life…

    • 2971 Words
    • 12 Pages
    Better Essays
  • Good Essays

    “Nutrition is the science that links foods to health and disease. It includes the processes by which the human organism ingests, digests, absorbs, transports, and excretes food substances.” (UOP, 2011). Nutrition is a vital aspect to developing and maintaining good health. Nutrition is essential to our daily lives because it does affect an individual’s quality of life and how long that life is. Lazy lifestyles along with poor diets are risk factors that cause chronic diseases.…

    • 1704 Words
    • 7 Pages
    Good Essays
  • Good Essays

    Three Day Food Intake

    • 855 Words
    • 4 Pages

    Gordon, M., & Smith, A. M. (2011). Contemporary Nutrition (8th ed.). New York, New York: Mc graw hill.…

    • 855 Words
    • 4 Pages
    Good Essays
  • Powerful Essays

    Female Athlete Triad

    • 1949 Words
    • 8 Pages

    The female athlete triad is a health condition in which active women experience three inter-related disorders due to unhealthy body weight and eating habits. In the case of the triad, the word active refers to females who display moderate to high intensity levels of performance. The rate of performance must be high in order to counterbalance the decrease in calorie intake. Females who perform at a high intensity are at risk for the triad since they do not take in enough calories to fulfill the amount expended. The three disorders within the female athlete triad are osteoporosis, disordered eating, and menstrual dysfunction. Not all females experience all three of the conditions, however new data has indicated that even having one or two elements of the triad can greatly increase a female’s long term morbidity and mortality rate (6). Adolescent girls and women are the two categories who are mainly affected by the triad. The causation of this disorder is mainly due to the pressure placed on these females to maintain a slim body image in order to enhance their sports performance. The female athlete triad does not only affect elite athletes, it also affects active women and girls participating in physical activities. If females compete at elite levels and do not consume the adequate amounts of calories, vitamins, and/or water, then they will develop the female athlete triad.…

    • 1949 Words
    • 8 Pages
    Powerful Essays
  • Good Essays

    Nutrition Assessment

    • 1001 Words
    • 5 Pages

    Nutrition is an essential part in everyone’s life. It helps us stay healthy and energetic, look nice and be in a good mood. It plays a great role for the overall condition. And there is a great difference what you eat and how many vitamins and useful elements every food item includes. The analysis of the daily nutrition record helps realize whether a person consumes the right food in the right quantity.…

    • 1001 Words
    • 5 Pages
    Good Essays
  • Good Essays

    According to Wardlaw and Smith (2011) “Nutrition is the science that links foods to health and disease. It includes the processes by which the human organism ingests, digests, absorbs, transports, and excretes food substances” in which the body needs to be able to function each day. Each individual has their own nutritional needs that will enable them to stay healthy and deal with disease. Healthy nutrition can also help an individual with their different levels of activities, and how their brain functions through tasks.…

    • 1676 Words
    • 5 Pages
    Good Essays

Related Topics