INTRODUCTION Both scarring and nonscarring alopecias have been described with long-term use of epidermal growth factor receptor (EGFR) inhibitors. Current treatments revolve around anti-inflammatory agents such as topical corticosteroid ointments‚ creams‚ and intralesional injections to reduce follicular inflammation. Unfortunately‚ none of these therapies are universally effective. Here‚ we describe a case of erlotinib-induced alopecia refractory to intralesional and topical corticosteroids that
Premium Chemotherapy Skin Inflammation
Botulinum neurotoxins (BoNTs) are the most potent toxins known and the causative agent of botulism. Their exceptional toxicity is caused by the highly efficient inhibition of neurotransmitter release at the neuromuscular junction. High affinity binding of BoNTs is mediated by the simultaneous interaction with lipid embedded synaptic vesicle proteins and gangliosides the presynaptic membrane according to the well-established dual-receptor binding model. One peculiarity that is especially pronounced
Premium Protein Cell membrane DNA
BUAD 490 3/14/13 Team Written Case Analysis (Concise) Biodel‚ Inc. BIODEL INC. EXECUTIVE SUMMARY Biodel’s use of biotechnology expertise in the three prime areas of Cell Biology‚ Molecular Biology‚ and Immunodiagnostics has led their company into some great opportunities. Biodel created a synthetic serum to replace fetal calf serum and horse serum‚ and provide a more consistently available product for scientific researchers. Biodel’s Molecular Biology division used DNA technology to
Premium Marketing DNA Molecular biology
The gaseous hormone ethylene has been shown to influence a diverse array of plant growth and developmental processes‚ thus it is critical for plants to optimize the ethylene production at developmental transitions as well as during stress response. Ethylene is derived from the amino acid methionine‚ which in the first step is converted to S-adenosyl-methionine (AdoMet) by AdoMet synthetase3‚4. The 1-Aminocyclopropane-1-Carboxylic acid Synthase (ACS) catalyzes the conversion of AdoMet to 1-aminocyclopropane-1-carboxylic
Premium Protein DNA Gene
The nonmutated form of DMPK functions in the production of protein kinase serine; this enzyme plays a role in intracellular communication and in the regulation of myosin phosphate. When DMPK is mutated‚ the proteins CUG-BP1‚ MBNL1 and INSR are displaced causing the splicing of troponin pre-mRNA which causes malfunctions in the cardiac conduction system‚ dominance of a chloride channel that causes myotonia‚ dominance of an insulin receptor that affects the sufficiency of insulin‚ and dominance of
Premium Protein DNA Gene
nikhil teja DIGITAL SIGNAL PROCESSING A signal is defined as any physical quantity that varies with time‚ space or another independent variable. A system is defined as a physical device that performs an operation on a signal. System is characterized by the type of operation that performs on the signal. Such operations are referred to as signal processing. Advantages of DSP 1. A digital programmable system allows flexibility in reconfiguring the digital signal processing operations by changing
Premium Digital signal processing Signal processing Modulation
Ranger and Tonto Fistfight in Heaven” and then the movie Smoke Signals based on one story from this volume- Thus Is What it Means to Say Phoenix‚ Arizona- try to present the image of the real Indian in the real life and work against this “formerly-held stereotypes to form a new‚ uniquely Spokane identity” all these in a humorous‚
Premium Sherman Alexie Smoke Signals Native Americans in the United States
Digital signal processing Digital signal processing Digital signal processing (DSP) is the mathematical manipulation of an information signal to modify or improve it in some way. It is characterized by the representation of discrete time‚ discrete frequency‚ or other discrete domain signals by a sequence of numbers or symbols and the processing of these signals. The goal of DSP is usually to measure‚ filter and/or compress continuous real-world analog signals. The first step is usually to
Premium Digital signal processing
Lab manual for Digital Signal Processing Lab III B. Tech II Semester Prepared by J. Sunil Kumar‚ P.Saritha & Ch.Sateesh kumar reddy Department of Electronics & Communication Engineering Turbomachinery Institute of Technology & Sciences (Approved by AICTE & Affiliated to JNTUH) Indresam(v)‚ Patancheru(M)‚ Medak(Dist). Pin: 502 319 Date:………… DSP Lab Manual ……… Turbomachinery Institute of Technology & Sciences Certificate This is to certify that Mr. / Ms. ………………………………….
Premium Finite impulse response Digital signal processing
EE2 Signals and Linear Systems Pier Luigi Dragotti Electrical & Electronic Engineering Department Imperial College London URL: http://www.commsp.ee.ic.ac.uk/~pld/Teaching/ E-mail: p.dragotti@imperial.ac.uk PLD Autumn 2012 Thursday‚ 27 September 12 Signals and Linear Systems Lecture 1 Aims and Objectives “The concepts of signals and systems arise in a variety of fields and the techniques associated with these notions play a central role in many areas of science and technology
Premium Digital signal processing Fourier transform