2009 Received in revised form 19 August 2009 Accepted 20 August 2009 Available online xxx Keywords: COX-2 Thromboxane synthase Lipoxygenase Homology modelling Docking In an effort to develop potent anti-inflammatory and antithrombotic drugs‚ a series of new 4-(2phenyltetrahydrofuran-3-yl) benzene sulfonamide analogs were designed and docked against homology models of human cyclooxygenase-2 (COX-2)‚ lipoxygenase and thromboxane synthase enzymes built using MODELLER 7v7 software and refined by
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In chapter two‚ the Student Fear Factor‚ from Rebecca Cox book the College Fear Factor‚ she explores how students’ fears effect their success and how students use fear management strategies to overcome these fears. Cox examines the anxiety students have about transitioning from high school to college. She notices that the autonomy when transitioning into adulthood provokes anxiety in some students having to do with new responsibilities all on their own. In relation to college‚ she notes “the stress
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choosing the best method‚ it seems that‚ it is suitable‚ but the basic question will be that: why this method? Modeling procedure will answer to this question3. One of the most widely used models‚ in survival analysis‚ is the Cox proportional hazards model4. The main assumption of the Cox regression model is proportional hazards. It means that‚ the hazard for an individual‚ is proportional to the hazard‚ for any other individual‚ or the hazard ratio‚ is constant over time5. If PH assumptions‚ be violated
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In Renee Sylvain’s "Land‚ Water‚ and Truth": San Identity and Global Indigenism‚ she talked about how the United Nations’ definition of indigenous people brought about a huge impact on the lives of many people especially to the San communities which are currently dispersed in the different regions of South Africa. According to the United Nations’ special rapporteur Jose Martinez Cobo:‚ indigenous groups‚ peoples and nations are those which‚ having an authentic coherence with pre-invasion
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while taking hardly any days off. This hero we have been waiting to discover is none other than Mrs. Cox‚ the sixth-grade English teacher at Leavenworth Elementary School. Along her journey to fame‚ her superhuman powers have strengthened‚ overcoming obstacles has become easier‚ and her ability to fight off monsters is not as hard as it used to be; therefore‚ Mrs. Cox reached her heroic stage
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Introduction The use of anti-inflammatories is widespread in the treatment of musculoskeletal injuries and pain (Paoloni et al. 2009). This has in part led to the common misconception that inflammation is an inherently negative occurrence which needs to be stopped or at least limited rather than the essential healing process that it is (Garnham‚ 2009). In this case study the use of anti-inflammatories for a common musculoskeletal complaint will be discussed with the impact on the prescribing clinician’s
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Slide 1 My topic was the Case of Richard Jewell and the Media Mistreatment he endured. Slide 2 The 1996 Summer Olympic Games were underway in Atlanta Georgia Richard Jewell was working as a security gaurd at Centennial Park during a late night concert event. Jewell noticied an unattended knapsack left under a bench. He quickly notified federal agents who determined there was a bomb inside. Jewell and other personel started to quietly evacuate the area. 15 minutes later an unidentified
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CLINICAL PROBLEMS A 26-year-old woman comes to an allergy clinic complaining of a runny nose and itching eyes. The symptoms become particularly severe during the spring months. She has tried over-the-counter antihistamines and they help reduce the symptoms‚ but also cause side effects that she finds intolerable. 1. Which of the following drugs would you not recommend? A. Cetirizine B. Desloratadine C. Diphenhydramine D. Fexofenadine E. Loratadine A 45-year-old man is to undergo
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My interview with Ms. Renee Kopp a Special Education Preschool Teacher who closely works with students with ASD‚ the interview took place March 2‚2018 at Kester Elementary school. She has been working with LAUSD for 40 years. She began working as a teacher when she was 25 years old and became a special education teacher 5 years later. She received her bachelor’s degree in the field of Early childhood education and received her master’s degree in special education. Ms. Kopp is my sons former and
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International Finance Bencol: Raisio’s Global Nutriceutical Case International Penetration The case of Raisio’s effort to penetrate the global market reveals that the international market‚ while rewarding in a lot of ways‚ is also very complicated. Much of the complications come from different government regulations in each country it tried to penetrate. While the product itself has been wanted by the international market‚ as long as the processes required by the government haven’t been
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