The Iodination of Salicylamide Questions: 1. a) The possible sites of iodination of the salicylamide ring is on the ortho/para position to the -OH group. b) The most likely site of iodination is the para position. This spot has the least steric hindrance and is favorable due to the directing effects of the -OH and the withdrawing effects from the carbonyl. 2. The homo surface shows that salicylamide has large electron density at the para and ortho positions. These sites are more likely
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was Thin Layer Chromatography (TLC) with silica adsorbent as the stationary phase and 0.5% glacial acetic as the mobile phase. In one plate‚ five known samples were used as the reference‚ that is: Aspirin; Caffeine; Ibuprofen; and Salicylamide. Aspirin and Salicylamide were the only samples that fluoresced. On a second plate‚ the tablet sample was developed. The results of the lab showed that the unknown tablet had an Rf value of 0.51 and fluoresced. This related to Tylenol in the reference plate
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Estimation of the Activation Energy for the Iodination of Acetone Through the Effect of Temperature on the Rate Constant Joel Costa‚ Alex Fuentes‚ Michael Chea‚ Rex Nwerem Dr. Morgan Ferguson July 9‚ 2013 ABSTRACT | It is often important to determine the rate at which a chemical reaction takes place‚ i.e.‚ how fast it yields the desired products. Temperature is one of the factors that influence the rate of reactions and it does so by providing energy to reactant particles so that a larger
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Rates of Reaction: Iodination of Acetone Introduction: The rate at which a chemical reaction occurs depends on several factors: the nature of the reaction‚ the concentrations of the reactants‚ the temperature‚ and the presence of possible catalysts. In this experiment you will study the kinetics of the reaction between iodine and acetone in acid solution: For this reaction‚ you will determine the order of the reaction with respect to acetone and HCl and find a value for the rate constant‚ k.
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Electrophilic Aromatic Iodination of Vanillin Purpose: The purpose of this laboratory experiment is for an aromatic compound to undergo an electrophilic substitution reaction. To carry this out‚ our method combines sodium iodide and common bleach as the oxidizing agent in aqueous alcohol as the solvent. Balanced Chemical Equations: Physical Properties: Name of Chemical Chemical Structure Molar Mass (g/mol) BP/MP (ºC) Density (g/mL) Mass/Vol. Used Purpose 3-methoxy-4-hydroxybenzaldehye
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The Kinetics of the acid-catalyzed iodination of propanone Raw Data: Solution A:Propanone 2M Solution B: Iodine 0.005M Solution C: Sulfuric acid 1M Solution D: Distilled water Table 1 Experiment Volume of solution A ±0.05 (cm3) Volume of solution B ±0.05 (cm3) Volume of solution C ±0.05 (cm3) Volume of solution D ±0.05 (cm3) Total Volume ±0.2 (cm3) 1 2 2 2 4 10 2 4 2 2 2 10 3 6 2 2 0 10 4 2 1 2 5 10 5 2 0.5 2 5.5 10 6 2 2 4 2 10 7 2 2 6 0 10 Table 2 Experiment Time for yellow color to disappear
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Lab Report Iodination of Acetone Temperature as a Variable Objective The objective of this lab is to determine the energy of activation of the iodination of acetone. This will be done by performing the reaction at differing temperatures. The same reaction orders we obtained for the previous lab will be incorporated into this experiment. The equation Ea = -8.31 x slope of ln k vs. 1/T(K) will be used to determine the energy of activation required for this this reaction. Hypothesis
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! Isolation of the Components of BC Powder Introduction Aspirin‚ Caffeine and Salicylamide were extracted from an over-the-counter pain reliever (BC Powder). These components were separated by manipulating their solubilities by adjusting the acidity and basicity of the solution. By doing this‚ the three components were forced into conjugate acid (or base) forms‚ causing selective solubility in either an aqueous or organic solvent. These layers were then separated by use of a separation funnel
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then taken of each spot on the plate. The Acetaminophen had a value of 0.323‚ Aspirin had a value of 0.597‚ Caffeine had a value of 0.081‚ Unknown 154 on the first plate had 3 different values; 0.081‚ 0.306‚ 0.597‚ Ibuprofen had a value of 0.698‚ Salicylamide had a value of 0.587‚ and Unknown 154 on the second plate had three different values as well; 0.079‚ 0.397‚ and 0.587. Through analysis it was determined that unknown 154 was Aspirin. This was found by comparing the Rf values of all the analgesic
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experiment is to determine the components of an unknown drug and identify it as one of six (6) commercial drugs by using thin-layer chromatography. I added approximately a quarter of a tablet of acetaminophen‚ aspirin‚ caffeine‚ ibuprofen‚ salicylamide‚ and the unknown (#19) to separate test tubes containing 2.5mL of dichloromethane. I noticed that my unknown was a coated tablet. Each test tube was swirled until the greatest amount of each solid was dissolved. Each solution was spotted along
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