Introduction - sickle cell anemia The first suggestion that genes might provide the information for all proteins came from Linus Pauling’s lab at Caltech. He and his student Harvey Itano studied hemoglobin‚ the protein in red blood cells that transports oxygen from the lung to metabolically active tissues‚ like muscle‚ where it is needed. In particular‚ they focused on the hemoglobin of people with sickle-cell disease‚ also known as sickle-cell anemia‚ a genetic disorder common in Africans‚ and
Premium Red blood cell Sickle-cell disease DNA
Adams 1 Dwayne Adams Instructor: Croshaw Medical Terminology 1 18‚ April 2013 Sickle Cell Anemia Sickle-cell Anemia is a genetic blood disorder caused by the presence of an abnormal form of hemoglobin molecules in which the red blood cells loose their disc-shape and become crescent shaped. The shape also known as “hemoglobin S”. unlike normal red cells which are usually smooth and malleable‚ tend to collect after releasing oxygen‚ and cannot squeeze through small blood vessels. The
Premium Red blood cell Sickle-cell disease Blood transfusion
SICKLE CELL ANAEMIA Sickle cell anemia is an inherited condition. People with sickle cell anemia inherit two copies of the sickle cell gene‚ one from each parent. The sickle cell gene makes abnormal hemoglobin called Hemoglobin-S. The sickle cell gene is a trait due to a change in ONE nucleotide in the DNA sequence that leads to a change in ONE amino acid that changes how the hemoglobin protein folds. This change in the structure of the hemoglobin protein leads to a change in the shape of
Premium Red blood cell Sickle-cell disease Hemoglobin
Sickle Cell Anemia first came into the view of the world around 1910 when Dr. James Herrick; a cardiologist‚ had a patient who complained of pain and described symptoms that sounded like anemia. He handed the case down to his assistant who‚ after taking a blood sample‚ discovered that the patient’s blood cells were not shaped like normal blood cells. When the patient’s blood cells were compared to normal blood cells‚ they appeared to be “sickle shaped”. After seeing this for himself Dr. Herrick took
Premium Medicine Patient Blood
Sickle Cell is an inherited blood disorder that affects approximately 100‚000 people in the United States. Red blood cells contain hemoglobin which is a protein that carries oxygen through the blood. Normal red blood cells are flexible and round. This allows them to travel through the small blood vessels and deliver oxygen to all of the body. Sickle cell disease(SCD) causes these red blood cells to form into a crescent shape‚ like a sickle. The sickle-shaped red blood cells easily break apart‚ causing
Premium Sickle-cell disease Red blood cell
Sickle cell anemia is a genetic disease that affects the shape and functionality of red blood cells. It is caused by a mutation in the DNA of the protein‚ hemoglobin‚ specifically in the beta chain. There are 531 base pairs in this DNA strand. Substitution or point mutation occurs‚ causing “GAG” to become “GTG”. This results in valine being created instead of glutamate. The mutation causes the hemoglobin to cling together in low oxygen levels and the red blood cell changes shape‚ preventing it from
Premium DNA Red blood cell Sickle-cell disease
Sickle-Cell Disease Greatly affecting the body’s oxygen levels due to mutated red blood cells‚ sickle-cell disease‚ influences an individual’s childhood in multiple ways: cognitive‚ social‚ emotional‚ and physical development. Sickle-cell disease (SCD) refers to an inherited disorder where abnormal hemoglobin is present in one’s red blood cells. Hemoglobin is the protein in red blood cells responsible for carrying oxygen throughout the body. The deformed sickle hemoglobin in people with SCD can form
Premium Blood Red blood cell Hemoglobin
Differential diagnose 1: Sickle Cell Anemia A 17-year-old African American female presented to the clinic with the following symptoms‚ chest and abdominal pain‚ and jaundice eyes. Her vital signs revealed B/P 98/50‚ pulse 112‚ respiration. 28 and temp. 99.9. EKG and chest x-ray completed with the result within normal range. She was discharged‚ and within four hours returned to the ER. Sickle cell disease is defined as a group of heredity disorder characterized by abnormal hemoglobin‚ called hemoglobin
Premium Red blood cell
Cell’s July 18‚ 2011 Sickle cell anemia is an inherited blood disease that means you are born with it and it lasts a lifetime. People with sickle cell anemia inherit two variant or sickle cell genes‚ one from each parent. In the United States‚ sickle cell anemia affects about 72‚000 people. About 2 million Americans carry the sickle cell trait but about 1 in 12 African Americans have the trait. The signs and symptoms of sickle cell anemia are different in each person. Some people
Premium Red blood cell Blood transfusion Sickle-cell disease
Critical Care Nursing: Sickle Cell Anemia Critical Care Nursing 10/15/2009 Sickle cell anemia affects millions of people worldwide. Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. They don’t last as long as normal‚ round red blood cells‚ which leads to anemia. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re
Premium Sickle-cell disease Red blood cell Hemoglobin