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The review focuses on how D. melanogaster can be utilized to answer questions about functions of genes involved in human diseases.
Review various human disease genes w/ identified homologous in D. melanogaster the availability of genome sequences of human and model organisms has provided a good opportunity to investigate the conservation of genes responsible for heritable diseases in human such as Neurological disorders, developmental disorders, Familial Alzheimer disease, Fragile X syndrome, Tuberous sclerosis, cancer, and Tumour metastasis. The database Homophila revealed that human disease genes are related closely to D. melanogaster. Disrupting the gene of D. melanogaster can cause many human like diseases. Thus the D. melanogaster fly model will aid in making human diseases’ genetic structure more comprehensive
What are some strengths and weaknesses of using the Drosophila model system for human disease research?
Strengths:
Analyses indicate that D. melanogaster can serve as a model for a wide array of gene functions involved in human disease
These fly disease models can be used to study the cell-biological basis for the degeneration phenotype. Studies have revealed that animals with similar developmental mechanism act throughout important process. similar developmental mechanisms act throughout bilateral animals to accomplish several important processes that include:
Specifying segment identity along the anterior–posterior axis; subdividing the ectoderm into neural versus non-neural domains along the dorsal–ventral axis; identifying the appendages outgrowth from the body, the formation of complex structures such as the eyes, the heart, the lungs and the immune system; the outgrowth of axons in the nervous system; and, potentially, controlling basic behaviors such as sleep or substance abuse.
Since there is genetic template we can use, scientist have used this to fill a niche between unicellular organisms such as yeast and the
The review focuses on how D. melanogaster can be utilized to answer questions about functions of genes involved in human diseases.
Review various human disease genes w/ identified homologous in D. melanogaster the availability of genome sequences of human and model organisms has provided a good opportunity to investigate the conservation of genes responsible for heritable diseases in human such as Neurological disorders, developmental disorders, Familial Alzheimer disease, Fragile X syndrome, Tuberous sclerosis, cancer, and Tumour metastasis. The database Homophila revealed that human disease genes are related closely to D. melanogaster. Disrupting the gene of D. melanogaster can cause many human like diseases. Thus the D. melanogaster fly model will aid in making human diseases’ genetic structure more comprehensive
What are some strengths and weaknesses of using the Drosophila model system for human disease research?
Strengths:
Analyses indicate that D. melanogaster can serve as a model for a wide array of gene functions involved in human disease
These fly disease models can be used to study the cell-biological basis for the degeneration phenotype. Studies have revealed that animals with similar developmental mechanism act throughout important process. similar developmental mechanisms act throughout bilateral animals to accomplish several important processes that include:
Specifying segment identity along the anterior–posterior axis; subdividing the ectoderm into neural versus non-neural domains along the dorsal–ventral axis; identifying the appendages outgrowth from the body, the formation of complex structures such as the eyes, the heart, the lungs and the immune system; the outgrowth of axons in the nervous system; and, potentially, controlling basic behaviors such as sleep or substance abuse.
Since there is genetic template we can use, scientist have used this to fill a niche between unicellular organisms such as yeast and the