VITAMIN D DEFICIENCY IN THE WELL FED CLASS OF PAKISTAN: THE POSSIBLE CAUSES AND TRENDS Yusra H. Siddiqui *, Rashid Minhas, Adnan Yaqoob, Samina Shakeel Department of Biochemistry, Quaid-e-Azam University, Islamabad, Pakistan
This population-based survey was conducted to determine frequency of vitamin D deficiency in the twin cities of Pakistan. 1000 patients were evaluated for tests of circulating 25-hydroxy-vitamin D (25-OHD) levels using electrochemiluminescence method. Median 25-OHD was 14.73 ng/ml, 14.12 ng/ml in females and 16.51 ng/ml in males. Their mean age was 45.02 years. 73 % had vitamin D deficiency (males 20.7% ; females 79.2% ), 16 % had insufficiency (males 25.7%; f emales 72.9%) and only 11 % were vitamin D sufficient (males 29.1%; f emales 70%). T-test and C hi-square t est w ere d one an d a marked p attern observed i n m ales was t hat af ter 50 t hey t end to be l ess vi tamin D d eficient.These dat a conclude that vitamin D d eficiency is ex tensive in t he t win c ities of P akistan an d s uggest that routine monitoring of vitamin D levels may be of benefit. Key words: Vitamin D; Blood levels; Rickets; Osteomalacia; Bone problems
Several important developments ha ve regenerated interest in vitamin D. Serum 25-hydroxy-vitamin D (25OHD) is widely r ecognized as t he best m easure of vitamin D status a nd its r ole in the maintenance of t he immune, reproductive, muscular, s keletal a nd integumentary sy stem i s be ing extensively acknowledged (Whiting and Calvo, 2005). Vitamin D de ficiency appeared dur ing t he i ndustrial revolution and at the beginning of the twentieth century an out break of the vitamin D deficiency disease r ickets occurred among urbanised young children on bot h sides of the Atlantic...