APInterventions and Practices Considered
Measures to achieve safe mechanical ventilation
Measures to prevent aspiration
Selective use of antibiotics to control outbreaks
Note: Routine use of oral and systemic antibiotics was considered but not recommended. 5.
Oral care with antiseptic agents
Daily interruptions or lightening of sedation and avoidance of paralytic agents 7.
Gastrointestinal bleeding prophylaxis with either H2 antagonists or sucralfate 8.
Transfusion of red blood cell and other allogeneic blood products in selected patients 9.
Insulin therapy if indicated
Major Outcomes Considered
Length of stay in intensive care unit (ICU)
Morbidity and mortality
Incidence of healthcare-associated infections
Interventions and Practices Considered
Elevation of the head of the bed
Maintaining cuff pressure in the endotracheal tube between 20-25 mmHg 3.
Use of heated humidifiers and heat and moisture exchangers 5.
Providing oral care with chlorhexidine and water-soluble mouth moisturizer 6.
Secretion removal with specially designed endotracheal tubes 7.
Closed, in-line suctioning (no recommendation made)
Evaluation for kinetic bed therapy
Assessment of weaning readiness with brief weaning trials 11.
Stress ulcer disease prophylaxis
12. Deep vein thrombosis prophylaxis
Ventilator-associated Pneumonia (VAP)
Ventilator-associated pneumonia is a lung infection that develops in a person who is on a ventilator. A ventilator is a machine that is used to help a patient breathe by giving oxygen through a tube placed in a patient’s mouth or nose, or through a hole in the front of the neck. An infection may occur if germs enter through the tube and get into the...
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