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Scrub Typhus Research Paper

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Scrub Typhus Research Paper
Scrub typhus is a mite-borne rickettsioes. The pathogenic agent is Orientia tsutsugamushi, which is a gram-negative obligate intracellular bacterium. Serotypes of O. tsutsugamushi includes Karp, Kato, Gilliam, Boryon, Kawasaki, and Koroki, it is different antigenicity (28). Chigger or thrombiculid mite, which is a larva of the genus Leptotrombidium mites, is vector of O. tsutsugamushi. Transmission of orientiae to human accidentally occurs through the biting of infected chigger (29). In general, orientiae infects in various cell type including endothelial cells, macrophages, and leukocytes. It invades endothelial cells and multiples by binary fission. Invasion of endothelial cells results in cell membrane disruption and releasing
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