Pathogenesis Research Paper
Pathogenesis. Basically, ALI is an acute lung inflammation that causes disruption of the pulmonary alveolar- capillary barriers (alveolar epithelium, interstitium, and microvascular endothelium), which occurs in three phases; acute or exudative phase, resolution phase and fibrotic phase [8,9].
1. Acute or exudative phase (<72h), which characterized by a disruption of the alveolar capillary membrane leading to leakage of protein rich fluid into the interstitium and alveolar space, and extended release of cytokines and neutrophil infiltration of the alveolar space (Figure 1) [8,18]. Pathogenesis of acute phase associates with a variety of cellular and molecular mechanisms, including transepithelial neutrophil infiltration, microvascular endothelial
1. Acute or exudative phase (<72h), which characterized by a disruption of the alveolar capillary membrane leading to leakage of protein rich fluid into the interstitium and alveolar space, and extended release of cytokines and neutrophil infiltration of the alveolar space (Figure 1) [8,18]. Pathogenesis of acute phase associates with a variety of cellular and molecular mechanisms, including transepithelial neutrophil infiltration, microvascular endothelial