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Edexcel GCE

Biology
Advanced Subsidiary
Unit 1: Lifestyle, Transport, Genes and Health
Thursday 8 January 2009 – Morning
Time: 1 hour 15 minutes
You do not need any other materials.

Paper Reference

6BI01/01
Total Marks

Instructions
se b
ink or
• Uill inlack boxesball-point pen. page with your name,
a the top of this
• F the andt candidate number.
centre number
uestions.
• Answer all qquestions in the spaces provided
the
• Answermay be more space than you need.
– there

Information
paper
• The total markefor thisuestion is 80.shown in brackets
T
ach q
are
• –hesemarks forguide as to how much time to spend on each question. u this as a
ability to
information,
• You will be assessed on yourclearly andorganise and presentyour use of ideas, descriptions and arguments
logically, including



grammar, punctuation and spelling.
Candidates may use a calculator.

Advice
ead
carefully
• Reep each questiontime. before you start to answer it.
K
• Try toan eye on the question.
• Checkanswer every if you have time at the end.
• your answers

Turn over

N34406A
©2009 Edexcel Limited.

1/1/1/1/1/

*N34406A0124*

Answer ALL questions.
Some questions must be answered with a cross in a box . If you change your mind about an answer, put a line through the box and then mark your new answer with a cross . 1 Read through the following passage that describes the process of blood clotting, then write on the dotted lines the most appropriate word or words to complete the passage.

(6)
A blood clot may form when a blood vessel wall becomes damaged. Cell fragments called .......................................................... stick to the wall of the damaged blood vessel forming a plug. A series of chemical changes occur in the blood, resulting in .......................................................... being converted into thrombin. Thrombin is an .......................................................... that catalyses the conversion of .......................................................... into long insoluble strands of .......................................................... . These strands form a mesh that trap .......................................................... to form the clot. (Total for Question 1 = 6 marks)

2

*N34406A0224*

2 Transcription and translation are two main stages in protein synthesis. (a) Complete the table below by writing the word transcription or translation next to the appropriate statement about protein synthesis.

(5)
Statement

Stage of protein synthesis

Ribosomes are involved
DNA acts as a template
tRNA is involved
Peptide bonds are made
mRNA is made

*N34406A0324*

3

Turn over

(b) The table below shows some amino acids and their corresponding DNA triplet codons. The DNA triplet codons for a stop signal are also shown. Amino acid / stop signal

DNA triplet codons

Proline

GGT GGG GGA

Alanine

CGG CGA CGT CGC

Cysteine

ACA ACG

Serine

AGG AGA AGT AGC

Leucine

GAA GAG GAT GAC

Arginine

GCA GCG GCT GCC

Glutamine

CTT CTC

Glycine

CCT CCG CCA CCC

Threonine

TGC TGA TGT TGG

Stop signal

ATT ATC ACT

The diagram below shows part of a DNA molecule.
codon 84
A

C
(i)

A

codon 85
C

T

Place a cross

T

codon 86
A

C

A

codon 87
G

C

C

codon 88
G

G

T

codon 89
G

G

G

in the box next to the amino acid coded for by codon 85.
(1)

Leucine
Glutamine
Glycine
Serine
(ii) Place a cross in the box next to the sequence of amino acids found in the polypeptide chain that is coded for by this part of the DNA strand. (1)
cysteine glutamine cysteine arginine proline proline
threonine leucine threonine alanine glycine glycine
cysteine glutamine cysteine arginine glycine glycine
cysteine proline cysteine arginine proline proline...
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