Meiosis: Chromosomes

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Meiosis
BIOL 1111

Introduction
Meiosis is the second important kind of nuclear division. It resembles mitosis in many ways but the consequences of meiotic divisions are very different from those of mitotic divisions. While mitotic division may occur in almost any living cell of an organism, meiosis occurs only in special cells. In animals, meiosis is restricted to cells that form gametes (eggs and sperm). Each species has a characteristic number of chromosomes per somatic cell. Fruit flies have 8; normal humans have 46. They exist as homologous pairs (partners) that are similar in size and shape and carry the same kinds of genes. Thus humans have 23 homologous pairs. The full complement of 46 chromosomes is referred to as the diploid number (referring to the fact that each kind of chromosome is represented twice). In higher organisms when an egg is fertilized the egg and sperm fuse to form a single cell called a zygote which develops into a new organism. If the egg and sperm were both diploid (46 chromosomes each in the case of humans) then the resulting zygote would be tetraploid. This would be an intolerable situation, so a mechanism has evolved to insure that each gamete (egg or sperm) contains only one representative of each homologous pair (or half the diploid number). This is referred to as the haploid number. The mechanism that makes this possible is meiosis. Meiosis consists of two divisions, Meiosis I and Meiosis II, and can potentially result in the production of four cells. However the DNA is only synthesized once (prior to Meiosis I). The subdivisions of meiosis are named like the subdivisions of mitosis (prophase, metaphase, anaphase, telophase) but as we shall see the events are somewhat different. To understand the physical processes involved in meiosis, we will use pipe cleaners as models of chromosomes. The first step will be to determine the types of chromosomes that exist and the genotype and phenotype of the cell. We will then manipulate the chromosomes to stimulate Meiosis I (Prophase I, Metaphase I, Anaphase I, Telophase I and Cytokinesis). At the end of Meiosis I we will determine the genotypes carried by each daughter cell produced. Then we will stimulate Meiosis II (Prophase II, Metaphase II, Anaphase II Telophase II and Cytokinesis). At the end of Meiosis II we will stimulate fertilization by trading gametes with other lab groups and fusing two gamete nuclei to form diploid offspring. After fertilization, we will determine the genotype and phenotype of our new offspring. Each lab group will receive a “nucleus” (plastic bag) with 8 duplicated chromosomes (pipe cleaners). Each chromosome consists of two identical chromatids. Except for the two sex chromosomes, each chromosome is marked to show the location of certain genes. Since we are stimulating a diploid organism, each nucleus has two homologous chromosomes of each type. There are four types, long (A), medium (B), short (C) and sex. We will then use the chart below to interpret our chromosomes.

The Chromosomal Traits are as follows:

Long ChromosomeIA (red)IB (orange)i (Green)
Blood Type:Type A*Type B*Type O

Insulinnegativenormal*normal*

Medium ChromosomeB (brown)b (yellow)
Eye colorBrown*Blue

Hair colorBrown*Blonde

Short Chromosomec (pink)C (white)
Hair StyleStraightCurly*

Hemoglobinnormal*sickle-celled

Sex ChromosomeX Chromosome (black)Y Chromosome (blue)
Black/Black = Female
Blue/Black = Male
NOTE: * Indicates the dominate allele

Procedures
Determine Your Phenotype
Procedure:
We will then determine our chromosomes and list the characteristics of our individual. We will conclude the genotype and phenotype of as follows: blood type, insulin, eye color, Hair color, Hair style, Hemoglobin, and Sex. Hypothesis:

We had 4 long red pipes, 4 medium brown pipes, 4 white short pipes, 4 short black pipes that are used as symbols...
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