Log P Value Atenolool

Log P values: Log p value atenolol: 0.16 Log P value metoprolol: 1.8 Log P value of propranolol: 3.21 Reason: The distribution of a drug between water and octanol is one criterion to determine how lipophilic the compound is. The distribution coefficient (log P) gives an indication of how easily the drug is adsorbed, how strong the effect is, how long it remains in the body in an active form, and how it is metabolized and excreted. The partition coefficient is a ratio of concentrations of unionized compound between the two solutions. To measure the partition coefficient of ionizable solutes, the pH of the aqueous phase is adjusted such that the predominant form of the compound is unionized. The logarithm of the ratio of the concentrations of the unionized solute in the solvents is called log P. The log P value is also known as a measure of lipophilicity; greater the logP value, higher will be the lipophilicity. The distribution coefficient for ionizable
The net dipole moment of the molecule Atenolol has amide functional group that makes it the most polar out of three drugs. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent N–C dipole, allows amides to act as H-bond acceptors. The presence of N–H dipoles allows amides to function as H-bond donors as well. Therefore, atenolol is the most polar drug and can be assigned the lowest log P value i.e. 0.16. Propanolol is the least polar drug because it contains non-polar aromatic functional group. Benzene is rendered non-polar due to its high structural symmetry of pi system of p-orbitals that distributes the charge equally along the ring. Therefore, propranolol can be assigned the highest log P value i.e. 3.21. Metoprolol is more polar than propranolol due to oxygen atom in the ether functional group. It can act as H-bond acceptor. Therefore, it can be assigned the intermediate log P value i.e.