Liver Research Paper

Liver is one of the most important organs in human body, it helps in fighting infections, metabolizing drugs by producing enzymes, and synthesizing proteins like, albumin. Liver failure happens When the liver cannot adequately functions and it is life threatening condition if it’s not managed immediately, it might cause some complications, like cirrhosis, hepatitis and multi-organ damage.(1)Liver transplant might be a lifesaving solution with liver failure, unfortunately liver transplant have its own complication like, acute or chronic rejection, and graft loss. Although liver is considered an immune privileged organ due to t cell role in immune response ,though we must use immunosuppressive medications in post liver transplant surgery but in lower doses
In fact,50% of post liver transplant patients had an opportunistic infection after the surgery,70% accounts for bacterial infections.(3)(4),due to the continues screening and appropriate treatment for those infections, mortality rates are low (less than 10% )(new ref5).Another common post liver transplantation complication is metabolic syndrome which account in patients diagnosed with hypertension, dyslipidemia , hyperglycemia, and obesity. Immunosuppressive drugs accompanied with metabolic syndrome considered as the main risk factor for developing a cardiovascular complications.( 6).Obesity, especially central obesity is related more than peripheral to cardiovascular complications. Some normal weight patient became overweight after liver transplantation due to adjusted catabolic status which was previously caused by cirrhosis and has been resolved by the liver transplantation, increased appetite, and the use of steroids course after surgery.(6) Immunosuppressive drugs plays a role in metabolic syndrome in which it might contribute to hypertension in post liver transplant patients as it alters systemic and renal hemodynamics.