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Lamotrigine Orodispersible Tablets Lab Report

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Lamotrigine Orodispersible Tablets Lab Report
Formulation of Lamotrigine Orodispersible Tablets by Using New Generation Superdisintegrants

B.Ramu 1*, N.Ramakrishna 2, B.Shivashanker3
1,3 K.V.K College Of Pharmacy , Department Of Pharmaceutics,JNTUH Hyderabad India. 2 Avanthi institute of pharmaceutical sciences,department of pharmaceutics Bandameedi.ramu@gmail.com ABSTRACT
In the present work, an attempt has been made to develop fast disintegrating tablets of Lamotrigine. New generation super disintegrates Solutab, Explotab and Polyplasdone XL was selected as super disintegrates. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations …show more content…
Methodology:
Tablet formulation:
Formulation of Lamotrigine Dispersible Tablet by Direct- Compression 7:
Composition of preliminary trials for Lamotrigine Dispersible Tablet by direct compression is shown in table 6.1. All the ingredients were weighed. Required quantity of drug and excipient mixed thoroughly in a polybag. The blend is compressed using rotary tablet machine-10 station with 6mm flat punch, B tooling. Each tablet contains 2.5 mg Lamotrigine and other pharmaceutical ingredients .

Table 1. Formulation of Lamotrigine oro dispersible tablets
INGREDIENT F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 F11 F12
Lamotrigine 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5
Solutab 5 10 15 20
Explotab 5 10 15 …show more content…
New generation super disintegrates Solutab, Explotab and Polyplasdone XL was selected as super disintegrates. All the formulations were prepared by direct compression method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 97.54 % in 10 min hence it is considered as optimized formulation. The f4 formulation contains Solutab as super disintegrate in the concentration of 20 mg.F8 formulation also showed maximum percentage drug release i.e., 101.8% in 10 min ,it contains Explotab as super disintegrate in the concentration of 20
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