Human Chorionic Gonadotrophin

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  • Topic: Human chorionic gonadotropin, Pregnancy, Luteinizing hormone
  • Pages : 3 (638 words )
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  • Published : March 13, 2013
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Human Chorionic Gonadotrophin

About hCG:
• human chorionic gonadotropin (hCG) is a hormone produced during pregnancy that is made by the developing placenta after conception, and later by the placental component syncytiotrophoblast. • Made by cells that form the placenta which nourishes egg after fertilization

Structure of hCG:
• HCG is glycoprotein composed of 244 amino acids
Alpha sub unit- identical to LH, FSH, TSH
Beta sub unit- unique

Function:
• HCG interacts with LHCG receptor and promotes the maintainance of corpus luteum during beginning of pregnancy which causes secrete progesterone • Because of its similarity to LH, hCG can also be used clinically to induce ovulation in the ovaries as well as testosterone production in the testes. • Human chorionic gonadotropin also plays a role in cellular differentiation/proliferation and may activate apoptosis

Production:
• hCG can be extracted from urine of pregnant women or by genetic modification

Testing:
• Level can be detected by
Blood test: 11 days after conception
Urine test: 12-14 days after conception
• A single hCG reading is not enough information for most diagnoses. When there is a question regarding the health of the pregnancy, multiple testings of hCG done a couple of days apart give a more accurate assessment of the situation

Reference levels:

Guideline to hCG levels during pregnancy:
hCG levels in weeks from LMP-last menstrual period (gestational age)*: • 3 weeks LMP: 5 - 50 mIU/ml
• 4 weeks LMP: 5 - 426 mIU/ml
• 5 weeks LMP: 18 - 7,340 mIU/ml
• 6 weeks LMP: 1,080 - 56,500 mIU/ml
• 7 - 8 weeks LMP: 7, 650 - 229,000 mIU/ml
• 9 - 12 weeks LMP: 25,700 - 288,000 mIU/ml
• 13 - 16 weeks LMP: 13,300 - 254,000 mIU/ml
• 17 - 24 weeks LMP: 4,060 - 165,400 mIU/ml
• 25 - 40 weeks LMP: 3,640 - 117,000 mIU/ml
•...
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