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Thyroid Cancer

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Thyroid Cancer
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Thyroid Cancer in Women

Name: Talia Kuchan

Course: HL-S-380V M71

Date: November 11, 2012

Introduction

Thyroid cancer is admittedly the commonest endocrine malignancy often detected among young patients and frequently among the women. In most populations, the median age of its detection tends to be quite low, actually below 40 in most cases. It is currently the fastest growing cancers among women. Despite the fact that the cancer is still quite rare, it continues to be increasingly on the rise among women across the globe and especially pregnant women. Most experts are not quite certain on the causes despite the fact that they have been able to identify the risk factors at play.

Essentially, there are four main types of thyroid cancer: Follicular, papillary, medullary and anaplastic. Papillary and follicular thyroid cancers are jointly referred to as differentiated thyroid cancer since their prognosis is more favorable relative to the other types. Among most young women, their pregnancy periods are usually accompanied with differentiated thyroid cancer. The management of this type of cancer poses risks due to the concerns of maternal and fetal health. With most women experiencing rises in differentiated thyroid cancer during pregnancy with a prevalence rate of 14 per 100,000, it has become necessary to discern the management of the ailment (Smith, Danielsen, Allen & Cress, 2003)

Literature review

Differentiated thyroid cancer (DTC) has a higher incident among women within their reproductive ages. It has long been speculated that the association between human chorionic gonadotropin (HCG), estrogen and DTC exists. Numerous studies have pointed out an association between high parity and the risk of DTC in pregnant women (Kravdal, Glattre, & Haldorsen, 1991). However, the data on the association between DTC and estrogen seem to be gravely inconsistent with some studies indicating



References: Braunstein, G. (2011).Thyroid Cancer. Boston: Springer. D. S. Cooper, G. M. Doherty, B. R. Haugen et al.(2009).Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 19 (11), 1167–1214, 2009. Retrieved September 24, 2012 from http://www.ncbi.nlm.nih.gov/pubmed/19860577 M. L. Lee, G. G. Chen, A. C. Vlantis, G. M. K. Tse, B. C. H. Leung, and C. A. Van Hasselt(2005).Induction of thyroid papillary carcinoma cell proliferation by estrogen is associated with an altered expression of Bcl-xL. Cancer Journal, 11(2), 113– 121.Retrieved September 24, 2012 from http://www.ncbi.nlm.nih.gov/pubmed?term=Induction%20of%20thyroid%20papillary%2 0carcinoma%20cell%20proliferation%20by%20estrogen%20is%20associated%20with% 20an%20altered%20expression%20of%20Bcl-xL. McTiernan A. M., Weiss N. S., Daling J. R. (1984). Incidence of thyroid cancer in women in relation to reproductive and hormonal factors. Am. J. Epidemiology., 120: 423-435.Retrieved September 24, 2012 from http://aje.oxfordjournals.org/content/120/3/423 McTiernan A., Weiss N. S., Daling J. R. (1987). Incidence of thyroid cancer in women in relation to known or suspected risk factors for breast cancer. Cancer Res., 47: 292-295.Retrieved on September 24, 2012 from http://www.ncbi.nlm.nih.gov/pubmed/3791213 O. Kravdal, E. Glattre, and T. Haldorsen. (1991).Positive correlation between parity and incidence of thyroid cancer: new evidence based on complete Norwegian birth cohorts. International Journal of Cancer, 49(6) 831–836.Retrieved September 24, 2012 from http://www.ncbi.nlm.nih.gov/pubmed/1959987 Smith, L., Danielsen, B., Allen, M., & Cress, R. (2003). Cancer associated with obstetric delivery: results of linkage with the California cancer registry. American Journal of Obstetrics and Gynecology, 189(4), 1128-1135. Retrieved September 24, 2012, from http://www.ncbi.nlm.nih.gov/pubmed/14586366 W. J. Mack, S. Preston-Martin, L. Bernstein, D. Qian, and M. Xiang (1999).Reproductive and hormonal risk factors for thyroid cancer in Los Angeles County females. Cancer Epidemiology Biomarkers and Prevention, (8)11, 991–997.Retrieved September 24, 2012 from http://www.ncbi.nlm.nih.gov/pubmed?term=Reproductive%20and%20hormonal%20risk %20factors%20for%20thyroid%20cancer%20in%20Los%20Angeles%20County%20fem ales

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