Grignard Reaction Lab
Grignard reaction
Abstract:
In this laboratory, triphenylmethanol was synthesised from reacting benzophenone and bromobenzene using Grignard reaction. As the reaction was to set up to produce a Grignard reagent and then recrystallize it to obtain pure sample. The percentage yield obtained was 55% and its melting point was 161 co which is within the literature value 160-163 co. In addition to that the IR spectroscopy confirmed the molecule structure to be triphenylmethanol.
Introduction:
The Grignard reagents are alkyl magnesium halides, R-Mg-X were first introduced in 1900. These reagents are usually prepared by reacting one atom with one molecule or by other means magnesium and alkyl halide in the presence of dry alcohol free ether. …show more content…
Since it was discovered that the THF increases the reactivity of organic halides towards magnesium. Grignard reagents were prepared by aryl chlorides and vinyl halides in the THF solvent. However, these days the best way to react it is to add diethylene dibromide and to use magnesium in excess and its known as the best entertainment technique.
Grignard reagents are widely used in the synthesis of organic molecules and organometallic compounds. Grignard reagents are extremely reactive with Lewis acids such as water. Therefore, precautions were taken during the lab to ensure that the reaction was not ruined due to the presence of water, increase the percentage yield, and obtain more accurate results. These reactions tend to split into two groups: Addition of the Grignard reagent to a compound containing multiple bond group such as: Which is the process of addition of the R group of RMgX occurs at the less electronegative and the MgX group at the higher electronegative atom. Which means that the R group is the negative and the MgX group is the positive ends of the dipole in the …show more content…
In addition to a very good example; forming an ester is possible by reacting Grignard reagent with alpha-monochloroether.
Grignard reagents could be used in forming many different compounds such as acid anhydrides, acids, alkyl cyanides, primary amines, alkyl halides, Thioalcohols, sulphuric acids and Dithioic acids. The most common synthetic uses are:
Hydrocarbons: when a Grignard reagent is reacted with any compound containing active hydrogen, a hydrocarbon is formed in the presence of water or dilute acid as shown below Primary alcohols: a Grignard reagent may be used to form an alcohol by reacting it with dry oxygen and decomposing the product with
Abstract:
In this laboratory, triphenylmethanol was synthesised from reacting benzophenone and bromobenzene using Grignard reaction. As the reaction was to set up to produce a Grignard reagent and then recrystallize it to obtain pure sample. The percentage yield obtained was 55% and its melting point was 161 co which is within the literature value 160-163 co. In addition to that the IR spectroscopy confirmed the molecule structure to be triphenylmethanol.
Introduction:
The Grignard reagents are alkyl magnesium halides, R-Mg-X were first introduced in 1900. These reagents are usually prepared by reacting one atom with one molecule or by other means magnesium and alkyl halide in the presence of dry alcohol free ether. …show more content…
Since it was discovered that the THF increases the reactivity of organic halides towards magnesium. Grignard reagents were prepared by aryl chlorides and vinyl halides in the THF solvent. However, these days the best way to react it is to add diethylene dibromide and to use magnesium in excess and its known as the best entertainment technique.
Grignard reagents are widely used in the synthesis of organic molecules and organometallic compounds. Grignard reagents are extremely reactive with Lewis acids such as water. Therefore, precautions were taken during the lab to ensure that the reaction was not ruined due to the presence of water, increase the percentage yield, and obtain more accurate results. These reactions tend to split into two groups: Addition of the Grignard reagent to a compound containing multiple bond group such as: Which is the process of addition of the R group of RMgX occurs at the less electronegative and the MgX group at the higher electronegative atom. Which means that the R group is the negative and the MgX group is the positive ends of the dipole in the …show more content…
In addition to a very good example; forming an ester is possible by reacting Grignard reagent with alpha-monochloroether.
Grignard reagents could be used in forming many different compounds such as acid anhydrides, acids, alkyl cyanides, primary amines, alkyl halides, Thioalcohols, sulphuric acids and Dithioic acids. The most common synthetic uses are:
Hydrocarbons: when a Grignard reagent is reacted with any compound containing active hydrogen, a hydrocarbon is formed in the presence of water or dilute acid as shown below Primary alcohols: a Grignard reagent may be used to form an alcohol by reacting it with dry oxygen and decomposing the product with